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8 Cards in this Set
- Front
- Back
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block follicular I uptake
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1. perchlorate ClO4
2. thiocyanate SCN 3. ClO4>>SCN |
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Block TPO Organification
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1. propylthiouracil PTU
2. methimazole MMI 3. will stop downstream iodothyronine synthesis |
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Block resorption iodothyronine back into cell
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1. colchicine (gout)
2. Li (SIADH) 3. cytochalosine B 4. Iodine: paradoxical decrease thyroxine (wolf-chaikoff effect) |
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inhibition of 5' deiodinase type I
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1. PTU
2. class D drug 3 interferes w/ warfarin, digoxin, beta blocker metabolis 4. also used block TPO organification |
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block type I and II deiodinases
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1. sodium ipodate
2. iopanoic acid |
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Throid Storm Tx
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1. antipyretic
2. PTU (prevents peripheral conversino T4-T3) 3. beta bocker (propanolol) |
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HRT
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1. levothyroxine
2. liothyronine 3. Ca and Fe block absorption |
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HRT drug interactions
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1. estrogen increase TBG and decrease freeT4
2. barbituates increase levothyroxing and levothyronine metabolism 3. T4/T3: increase tricyclic antidepressant receptors, increase beta receptors, increase metabolism corticosteriods |
