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17 Cards in this Set
- Front
- Back
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Name three antifungals |
Amphotericin B
Ketoconazole
Flucytosine
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What types of antiviral drugs use inhibition of virus entry as a mode of action |
Amantidine
Tamiflu/Relenza |
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What does amantidine treat |
Treats infections with influenza A. |
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How does amantidine work |
Blocks hemagglutinin receptors on cells, so viruses cannot enter or be released |
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How does tamiflu/relenza work |
Broad spectrum, blockes neuraminidase enzymes in both infuenza A and B |
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What drugs use inhibition of nucleic acid as a mode of action |
Acyclovir
AZT |
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How does acyclovir work |
Mimics the structure of nucleotides and competes for sites on replicating DNA. Replication of the strand stops, ending viral life cycle. |
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What is acyclovir used to treat |
Oral/topical treatment of herpes infections |
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What was the first drug used to treat aids |
AZT |
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How does azt work |
Stops the action of reverse transcriptase - stops RNA from turning into DNA |
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How do protease inhibitors work |
These insert onto HIV protease, an enzyme that clips viral proteins into functional pieces. Viruses are then defective and unable to infect other cells |
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How do interferons work |
These are human based glycoprotein produced primarily by fibroblasts and leukocytes. Natural occurring antiviral within our own bodies. |
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What can interferons be used to treat |
hepatitis C, genital warts, Kaposi's sarcoma |
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What are examples of antimalarial drugs ? *antiparasitic* |
Quinine chloroquinine primaquine mefloquine |
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What are examples of antiprotozoan drugs? *antiparasitic* |
metronidazole (flagyl) quinicrine sulfonamides tetracyclines |
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What are examples of antihelminthic drugs? *antiparasitic* |
Mebendazole Thiabendazole Niclosamide Pyrantel Piperazine |
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Describe the method of action of interferon in viral infections |
1.Virus binds to receptors of host cell 2.signal sent to nucleus that directs cell to synthesize an interferon 3. Newly synthesized interferons are rapidly secreted by the cell into extracellular space 4. New interferons bind to host cell 5.Binding induces production of another class of proteins that inhibit viral multiplication by preventing translation of viral protein |
