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10 Cards in this Set
- Front
- Back
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Why is it important that naïve T cells require antigen-presenting cells to activate them, instead of just recognizing their peptide antigen? |
Second signal to prevent activation to self |
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What does S1P do? |
Takes T cells away from lymphnode |
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If an infected dc passes peptides to another dc, what mhc will the new dc use? |
MHC I |
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How does TCR signaling change the strength of adhesion between a T cell and APC?
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It modifies LFA1 to increase affinity |
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What is a T cell synapse? |
contact of APC and T cell |
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What molecules are found in a T cell synapse? |
TCR MHC, CD28 B7 |
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What molecule binds to ICAM |
LFA1 |
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How do co-receptors (CD4 or CD8) contribute to TCR signaling?
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increase affinity and signal transduction |
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What is the role of IL-2 in T cell activation?
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Proliferation |
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What does CTL4 does and how? |
inhibits activation by binding b7 tighter |
