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9 Cards in this Set
- Front
- Back
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What do Th cells do
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Help other cells of the immune system fulfil their function - e.g. activate B cells to produce antibodies; stimulate the phagocytic and killing activity of macrophages
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What do Tc cells do
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Kill tissue cells that have become infected with microbes
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What do CD8-class I and CD4-class II interactions do
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1. Strengthen the overall binding between APCs and T cells
2. Provide additional activation signals that synergies with those delivered to the T cells via the TCR |
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Give examples of proteins which constitute the 'immunoglobulin superfamily'
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T lymphocytes
HLA class I & II CD4 and CD8 |
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HLA class I
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Expressed by most cells of the body
Form interactions with CD8 proteins Has 3 alpha and 1 beta-micro globulin chains |
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Dendritic cells
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Activated by microbial molecules that bind to PCRs
Found in most tissues of the body Primary stimulating antigen presenting cell - can activate both Th & Tc cells |
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Dendritic cells
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Activated by microbial molecules that bind to PCRs
Found in most tissues of the body Primary stimulating antigen presenting cell - can activate both Th & Tc cells |
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Processing of antigen for HLA I
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1. Protein ENDOGENOUS antigens degraded by proteosome
2. Peptides generated transfer to ER via protein transporter peptides 3. Peptides associate with newly synthesised HLA I molecules 4. Peptide-HLA complexes are transported to cell surface for Tc cell recognition |
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Processing of antigen for HLA II
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1. Exocytosis of endogenous antigen to vacuole; degraded by enzymes
2. New HLA II associate with invariant chain in ER 3. Invariant chain is degraded; antigen peptide associate with HLA II 4. Peptide-HLA complex transported to cell surface - ready for Th cell recognition |
