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11 Cards in this Set
- Front
- Back
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this fungal infection is associated with septicemia and endocarditis in IV drug abusers - morphology?
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Candida albicals
psuedohyphae + budding yeasts in cold warm/tissue = germ tubes |
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what fungal infection is associated with meningits inAIDs, Hodgkins?
morphology? tx? |
Cryptococcus neoformans
morphology = encapsulated yeast = monomorphic - think pigeons latex agglutination in CSF india ink = capsular halos tx = amph B + flucytosine untile afebrile and culture is negative, then fluconazole |
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fungal infection that causes penumonia in AIDS, malnourished babies, and premature neonates and other imcp pts
appearance on H&e stain? CXr? |
pneumocystic jiroveci
honeycomb appearance CXR = patchy infiltrate with ground glass appearance |
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antifungal that is a thymidylate synthase inhibitor associated with bone marrow suppression
spectrum? typically used with? |
fluctyosine
spectrum = narrow (cryptococcus and candida) used wtih amph B or fluconazole |
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rx that inhibits ergosterol synthesis
major SE? |
Azoles
SE = gynemcomastia/ decreases P450 |
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inhibits sterol biosynthesis - systemic agents for superficial infection with dermatophytes
which alters taste? which is assoc with disulfiram like rx with ethanol? which is associated with p450 change? |
terbinafine - taste disturbance
griseofulvan - disulfiram-like rx with etoh; increases p450 |
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antifungal used to tx local systemic dimorphic infections
SE? mech? |
azoles
SE = gynecomastia, lowered P450 mech = inhibits synth of ergosterol leading to altered membrane permeability |
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used to tx systemic dimorphic fungal infections that have disseminated
SE? mech? |
amph B
SE = nephrotoxicity, lowered EPO, can lead to anemia and arrythmia mech = binds ergosterol to alter membrane permeability |
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tinea infections are treated with ______
mech? SE? |
topical azoles (miconazole)
mech? inhibits ergosterol synth SE = gynecomastia, low P450 |
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topical antifungal with same mechanism as amph B
major SE? major use? |
nystatin
stevens-johnson syndrome (blistering, F, sloughing of skin - think TEN) Candida (thrush) |
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give antifungal:
distrupts fungal membanes by binding to ergosterol in the membrane depresses biosynth of ergosterol by inhibition of CYP450 inhibits DNA and RNA synth = nucleoside analog depresses ergosterol biosynthesis by inhibiting squalene oxidase inhibits fiungal mitosis by interacting with microtubules - major use? depresses CW formation by inhibiting glucan synthesis - major use |
amph B + Nystatin (topical)
azoles (systemic and opportunistic mycoses) 5-FU (fluorocytosine) - cryptococcus and systemic Candida terbinafine - dermatophyte infections griseofulvan (tx of cutaneous mycoses unresponse to to topical agents -- like terbinafine -- causes disulfiram rx) caspofungin (candida, apsergillus - not very toxic) |
