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6 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Essential Hypertension
(Antihypertensive therapy) |
Diuretics, ACE-I, AT II receptor blockers, CCB
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Congestive Heart Failure
(Antihypertensive Therapy) |
Diuretics, ACE-I, Beta-B, K+-sparing diuretics
*B-Blockers used cautiously in decompensated CHF, CI in cardiogenic shock |
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Diabetes Mellitus
(Antihypertensive Therapy) |
ACE-I/AT II RBs, CCB, Beta-B, Alpha-B
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Hydralazine
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Mech: ^cGMP --> Smooth Muscle Relaxation. Vasodilates arterioles>Veins; Afterload Reduction
Clin Use: Severe HT, CHF 1st line therapy for HT in pregnancy. Toxicity: Compensatory Tachy, fluid retention, nausea, HA, angina. Lupus-like syndrome |
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Calcium Channel Blockers
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Non-Dihydro(Verapamil, Diltiazem)
Dihydro(Nifedipine, Amlodipine) |
Mech: Block voltage-dependent Ca channels of cardiac + smooth muscle--> Reduce Muscle Contractility
Clin Use: HT, angina, arrhythmias(Not Nifedipine), Prinzmetal's angina, Raynaud's Toxicity: Cardiac Depression, AV block (Non-dihydro), peripheral edema, flushing, dizziness & constipation. |
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Malignant HT Treatment
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Nitroprusside
Fenoldopam Diazoxide |
Nitro: Short acting, ^cGMP via NO. Cyanide Poisoning
Fenoldopam: Dopamine R agonist - Relaxes renal vasc smooth muscle Diazoxide: K+ channel opener, hyperpolarizes & relaxes vasc smooth muscle. Hyperglycemia (v insulin release) |
