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26 Cards in this Set
- Front
- Back
Cartilage consists of cells called ____ and an extracellular matrix composed of ____ and _______.
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chondrocytes, fibers, ground substance
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The principle macromolecules found in all cartliage are ___, ___, ____ and _____.
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collagen, hyaluronic acid, glycoproteins, proteoglycans
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The firmness of cartilage is produced by the electrostatic interactions between ____ fibers and the ____ side chains of matrix ____.
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collagen, glycosaminoglycans, proteoglycans
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The 3 types of cartilage are ____, ____ and ____.
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hyaline, elastic, fibrocartilage
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____ cartilage that covers the surface of the bones of moveable joints, is devoid of _____ and gets oxygen and nutrients through diffusion from ____.
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articular, perichondrium, synovial fluids
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___ cartilage is the most common common, as well as the temporary skeleton of the embryo.
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hyaline
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In routine histology preperations of hyaline cartilage collagen is not visible because it is in the form of ____ and has the same ____.
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fibrils, refractive index of its ground substance
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The bulk collagen in hyaline cartilage is type ___, while type ___ regulates size, type ___ enhances fibril binding with proteoglycans, and type X _____.
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II, XI, IX, is involved in 3D arrangement
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Proteoglycans of ground substance contain 3 types of GAGs, ____, ____, and ____, which are linked to _____ acid to form ____.
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chondroitin 4-sulfate, chondroitin 6-sulfate, keratin sulfate, hyaluronic acid, proteoglycan aggregates
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____ mediates the binding of chondrocytes to the extracellular matrix by binding to GAGs and collagen type II.
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chondronectin
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Except in the _____ of joints, all hyaline cartilage is covered by the _____.
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articular cartilage, perchondrium
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Solvation water bound to the negative charges of ____ act as a ____.
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glycosaminoglycans, shock absorber
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Around the lacunae, chondrocytes have a higher concentration of ____ and less ____. This area is called the ____.
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sulfated proteoglycans, collagen, territoral or capsular matrix
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The area between lacunae that stain less heavily
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interterritorial matrix
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Pericondrium is rich in collagen type ___ and contain _____, with ____ in the inner layer that differentiate into chondrocytes.
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I, fibroblasts, chondroblasts
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____ groups are formed from mitotic division of a single chondrocyte into upto 8 cells.
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isogenous
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Chondrocytes have well developed ___ and ___, and produce ____, ___, _____ , and adhesive ____.
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RER, Golgi, Collagen II, GAGs, proteoglycans, glycoproteins
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Chondrocyte synthesis of sulfated GAGs are stimulated by ____, ___, and ___, and slowed by ___, ___, and ____.
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growth hormone, testosterone, thyroxine, cortisone, hydrocortisone, estradiol
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Cartilage growth depends on growth hormone _____, which stimulates synthesis of ____ in the liver that acts directly on the cells.
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somatotropin, somatomedin C
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____ growth results from the mitotic division of preexisting chondrocytes, and ___ growth results from the differentiation of perichondrial cells.
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interstial, appositional
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___ cartilage growth occurs in early phases of cartilage development, and in the epiphyseal plates of long bones within ____ cartilage.
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interstitial, articular
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___ cartilage is identical to hyaline cartilage except it contains elastin fibers.
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elastic
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___ cartilage is located in the pinna of the ear, external and internal auditory tubes, epiglottis and larynx.
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elastic
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___ is a tissue intermediate between dense CT and hyaline cartilate
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fibrocartilage
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Fibrocartilage does not have a ____ and is predominatly composed of collagen type ____.
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perichondrium, I
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____ carilage is located in intervertebral disc, symphysis pubis and the menisci of knee joint.
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fibrocartilage
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