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35 Cards in this Set
- Front
- Back
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What are the 2 different populations of T cells? |
Cytotoxic CD8 Helper CD4,Th1,2,fh |
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What are the 2 combinations for T cell receptor polypeptide chains? |
Alpha:beta Delta:gamma |
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How are T cells activated? |
MHC:peptide complex on DCs |
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Which IL mediates proliferation and differentiation of T cells? |
IL2 |
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Which cells are antigen presenting cells? |
Macrophages,dendritic cells and B cells |
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What does INF gamma do? |
Inhibits viral replication and activate macrophages |
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What do Th2 do? |
Mediate anit-parasitic response Activate macrophages |
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What does Tfh do? |
Mediate B cell activation |
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What does the interaction of CD40:CD40L do? |
Stimulates proliferation and differentiation into plasma cells in the germinal centre |
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What CD markers does delta:gamma have? |
CD3+,CD4,8- |
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What happens in alpha:beta T cells? |
Silence of gamma chain gene |
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Where are the MHC genes found? |
Short arm of chromosome 6 |
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What do MHC genes mediate? |
T cell development T cell recognition of antigen Rejection of tissue grafts Susceptibility to certain disorders |
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What T cells bind to MHCII? |
CD4+ |
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CD8+ T cells bind to which MHC? |
MHCI |
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What genes encode for class I? |
HLA-A,B,C |
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What genes encode for MHC II? |
DR,DQ,DS |
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What type of clefts does class 1 have? |
Closed |
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What type of clefts does class 2 have? |
Open |
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How is the peptide kept in place? |
Aplha helicies Aromatic and aliphatic residues |
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Which type of proteins does MHC 2 recognise? |
Vesicular proteins |
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What makes up the processing machinery of the MHC? |
Proteasome TAP transporter Clanexin PLC ERAAP invariant chain |
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What is the job of calnexin? |
Chaperone protein which stabalises MHC until pepetide fits |
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What does the PLC comprise of? |
Chaperone proteins |
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What is ERAAPS job? |
Trims peptides to correct length |
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Where is MHC built? |
ER |
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How does MHC counter replication by pathogens? |
Polygeny and polymorphism |
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For MHCII beta chains there 5 pseudo genes which ones are they? |
DRB-2,6,7,8,9 |
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What does the HLA-DQ sub region contain? |
2 alpha chains 3 beta chains 1 pseudogene |
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What does the HLA-DP sub region contain? |
2 alpha genes 2 beta genes |
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What genes are found on class III region? |
Complement components TNF cytokines |
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What cells take up antigens in the SI? |
M cells and DCs |
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Where do DCs present thier antigens? |
In the peyers patches |
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What type of cells predominate in the gut? |
CD8+ T cells |
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What do TH17 cells do? |
Secrete IL17 in the colon and ileum which acts on stromal cells and recruits neutrophils |
