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6 Cards in this Set
- Front
- Back
- 3rd side (hint)
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SYSTEMIC LUPUS ERYTHEMATOSUS》DEFINITION? |
an autoimmune, chronic, inflammatory, multi-systemic disease in which the body's immune system mistakenly attack healthy tissue in many parts of body |
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SLE》PATHOGENESIS? |
●immune complexes》deposit in tissue》inflammation (TYPE 3 HSR) ●immune response》phagocytosis & destruction esp. in some organs (TYPE 2 HSR) |
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SLE》ETIOLOGY? |
●genetic: -HLA DR3, C4A -F>M (×9) ; child-bearing woman -black race ●environmental: -UV light -smoking -drugs (procanamide, hydralazine, isoniazid) -estrogen.. |
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SLE》DIAGNOSTIC CRITERIA? |
☆≥4 of 11 criteria: ●SKIN: 1.malar rash (=butterfly) 2.discoid rash (chronic, can scar) 3.photosensitivity ●MUCOSA: (inner membrane) 4.ulcers (mouth, nose) ●SEROSA: (outer membrane) 5.serositis (pleuritis, pericarditis) ●JOINTS: 6.arthritis (≥2) ●KIDNEY: 7.renal disorders (proteinuria>0.5g/day, RBC casts) ●BRAIN: 8.neurological disorders (seizures, psychosis) ●BLOOD: 9.hematologic disorders (anemia, thrombocytopenia, leukopenia)》due to target ●ANTIBODIES: 10.ANTINUCLEAR ANTIBODY (ANA) 》very sensitive; not very specific! 11.OTHER ANTIBODIES a.anti-Smith (anti-Sm) 》+ specific b.anti-dsDNA 》during active disease c.anti-phospholipid c.1. anti-cardiolipin 》possible false+ for syphilis c.2. lupus anticoagulant c.3. anti-ß2 glycoprotein 1 |
MD SOAP BRAIN |
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SLE》TREATMENT? |
●PREVENTIVE: -avoid sunlight -infection ●LIMIT SEVERITY: -glucocorticoid -immunosuppresants -anti-malarials*: 》temel ilaç ¤chloroquine ¤hydroxychloroquine ¤quinacrine
*side eff: retina toxicity |
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SLE NEPHRITIS? |
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