Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
|
Epi of lupus |
Non-white women (AA) |
|
|
Criteria for Lupus |
Must have at least 4 of the following: *butterfly rash *photosensitivity *oral ulcers *discoid rash *arthritis (larger joints) *pericarditis/pleuritis *anemia, thrombocytopenia *renal disease (proteinuria >0.5g/day) *neuro (seizures, psychosis) *ANA *Anti-ds dna, anti-sm Ab |
|
|
test + in drug induced lupus |
anti-histone |
|
|
test of choice for lupus |
anti-ds dna |
|
|
C-ANCA + in what? |
Wegener's granulomatosis |
|
|
P-ANCA + in what? |
Polyarteritis nodosa |
|
|
Lupus tx |
NSAIDs avoid sun exposure Steroids for severe disease |
|
|
What does drug induced lupus not affect? |
CNS and kidneys |
|
|
CREST syndrome |
Calcinosis of digits Raynaud's Esophageal dismotility Sclerodactyly of fingers Telangiectases (digits and nails) |
|
|
Anticentromere Ab |
found in Limited Scleroderma |
|
|
Antitopoisomerase I Ab |
Diffuse Scleroderma (poorer prognosis. involves more-- lung, heart, GI, kidneys) Will also be ANA+ |
|
|
Main presentation of scleroderma |
Tightening of skin over fingers and face. Dysphagia and dyspepsia/GERD sx. Raynaud's |
|
|
Dry eyes and dry mouth |
Sjogren's syndrome |
|
|
What malignancy are sjogren's pts at increased risk for |
Non-hodgkin's lymphoma |
|
|
Dx of sjogren's |
ANA, RF, Ro (SS-A) and La (SS-B). ESR Schirmer test (filter paper put in the eye) Salivary gland bx is best test but not necessary for dx. |
|
|
what joints does RA spare |
DIP joints |
|
|
3 hand deformities of RA |
ulnar deviation of MCP joints
Boutonniere deformities Swan neck contractures |
|
|
Best test for RA |
anti-CCP Abs |
|
|
Tx of RA |
NSAIDs and low dose steroids for sx relief. DMARDs (methotrexate) |
|
|
Age for juvenile RA |
<16 yrs |
|
|
Presentation of JRA |
arthritis sx with more fevers and rashes |
|
|
Koebner's phenomenon |
rash elicited by scratching the skin; associated with JRA |
|
|
Still's disease |
with JRA; fever spikes and salmon rash |
|
|
Epi and eti of polyarteritis nodosa |
males 40-60 Inflammation of small and medium arteries; eti unknown. |
|
|
s/sx of polyarteritis nodosa |
fever, weakness, arthritis, peripheral neuropathy, abdominal angina. HTN Palpable purpura, livedo reticularis |
|
|
Dx of polyarteritis nodosa |
vessel bx. P-ANCA |
|
|
Polymyositis/dermatomyositis s/sx |
symmetrical proximal muscle weakness d/t inflammation of striated muscles
|
|
|
Skin changes associated with dermatomyositis |
heliotrope (around eyes, bridge of nose) Gottron's papules (red scaly lesions over knuckles) V-sign (Rash on chest) Shawl sign (shoulders, upper back, elbows, knees) Periungual telangiectases and hypertrophy of cuticles |
|
|
Dx of polymyositis |
CK increased, LDH, myoglobin Aldolase, ESR, CRP ANA Anti-Jo-1 and MI-2 Abs Muscle bx |
|
|
polymyositis tx |
steroids |
|
|
PMR presentation |
pain and stiffness in neck, shoulder and hip girdles (symmetric) worse in the morning |
|
|
PMR dx |
ESR >50 |
|
|
PMR tx |
steroids until disease resolves itself (about 2 yrs) |
|
|
Dx and tx of GCA |
temporal artery bx steroids to prevent blindness |
