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17 Cards in this Set
- Front
- Back
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What are the three main categories of renal disease?
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-pre-renal
-post-renal -intrinsic |
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T/F Identification of a clinical renal syndrome is the same as identifying the renal disease.
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False - multiple renal diseases can cause the same renal clinical syndrome
(biopsy tells about the renal disease) |
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What kinds of molecules are more freely filtered through the GBM?
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smaller and more positively charged
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What cells are responsible for the synthesis of GBM?
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Podocytes
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Patients with nephrotic syndrome have fewer _______________ and more ________________, allowing fewer small molecules and more larger molecules than normal to be filtered.
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small pores (from loss of filtration surface area)
large pores (from loss of slit diaphragm) |
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What kind of glomerular injury is associated with nephrotic syndromes like minimal change disease and FSGS?
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-podocyte injury (podocyte effacement)
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FSGS is associated with ____________ in renal mass.
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decrease
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Two forms of immune glomerular injury
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-subepithelial
-subendothelial/mesangial |
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Which is associated with nephrotic syndrome? Which is associated with nephritic syndrome?
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-subepithelial - nephrotic
-subendothelial - nephritic |
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Which is not associated with hypercellularity?
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Subepithelial - outside the GBM so not associated with leukocyte infiltration and hypercellularity, instead see capillary wall thickening
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Anti-GBM disease will show what pattern of IF? What are the antibodies generated to?
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-Linear
-A3 portion of the type IV collagen |
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What kind of glomerular damage is shown here?
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subepithelial
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What is shown here that can be a result of anti-GBM disease?
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crescent formation
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Glomerular damage of the type shown is associated with ____________ syndrome.
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nephritic
(subendothelial damage - note hypercellularity) |
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Progressive glomerular injury leads to __________________, at which point the mechanism of injury is no longer identifiable
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global glomerulosclerosis
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Podocyte injury can lead to what laboratory finding?
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Proteinuria
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T/F Podocytes are terminally differentiated and do not replicate
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True
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