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17 Cards in this Set

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Reactions in Mitochondria
**breakdown/energy pathways

MITO FATO:
FA oxidation
Acetyl-CoA production
TCA cycle
Oxidative phosphorylation

BOTH: HUGs take 2
Heme synthesis (1st and last steps- ALA synthase; ferrochetalase)
Urea cycle (CPSI, OTC)
Gluconeogenesis (Pyr carboxylase (pyruvate to oxaloacetate)
Reactions in cytoplasm
**synthesis reactions
Glycolysis, FA synthesis, HMP shunt, Protein synthesis (RER), steroid synthesis (SER)

Both:
Heme synthesis
Urea cycle
Gluconeogenesis
Rate-limiting step:
Glycolysis
phosphofructokinase-1
Rate-limiting step:
Gluconeogenesis
Fructose-1,6,bisphosphatase
Rate-limiting step:
TCA
Isocitrate dehydrogenase
Rate-limiting step:
Glycogen synthesis
Glycogen synthase
Rate-limiting step:
Glycogenolysis
Glycogen phosphorylase
Rate-limiting step:
HMP shunt
G6PD
Glucose-6-phosphate dehydrogenase
Rate-limiting step:
De novo pyrimidine synthesis
Carbamoyl phosphate synthestase II (in cytosol)
Rate-limiting step:
De novo purine synthesis
Glutamine-PRPP amidotransferase
Rate-limiting step:
Urea cycle
Carbamoyl phosphate synthetase I
(mitochondria)
Rate-limiting step:
FA synthesis
Acetyl-CoA carboxylase (ACC)
Rate-limiting step:
FA oxidation
Carnitine acyltransferase I
Rate-limiting step:
Ketogenesis
HMG-CoA synthase
Rate-limiting step:
Cholesterol synthesis
HMG-CoA reductase (target for statins)
Rate-limiting step:
Heme synthesis
Aminolevulinic Acid synthase (ALA synthase)
Rate-limiting step:
Bile acid synthesis
7-alpha hydroxylase