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9 Cards in this Set
- Front
- Back
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Adenosine
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P1 (forms as result of degradation of released ATP)
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ATP and ADP
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P2
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What does A1 do?
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blocks AV conduction and reduces cardiac contraction
inhibits transmitter release from central and peripheral nerve terminal reduces motor activity and induces sleep and anxiety renal vasoconstriction |
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A2?
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regulatory functions in the brain
vasodilation in coronary vessels inhibit platelet activation stimulation of carotid body afferents (causes hyperventilation) |
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A3?
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release mediators from mast cells
-bronchoconstriction |
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ATP NT?
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in peripheral adrenergic and cholinergic nerve terminals?
CNS and automonic ganglionic nerve terminals presynaptic inhibition of excitatory NT release |
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ATP non-neuronal transmitter mediated function?
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regulate cell surface K channels
regulates insulin secretion |
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What are P2 receptor-mediated functions?
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co-transmitter in sympathetic nerve terminals
leads to contraction of smooth muscle platelet activation increase in membrane permeability |
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Drug examples?
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Adenosine (inhibits AV conduction, stops supraventricular tachycardia)
methylxanthines, theophylline, caffeine (CNS stim) dipryridamole (blocks adenosine uptake - vasodilation and antiplatelet action) clopidogrel (ADP receptor anagonist) suramin (atp receptor antagonist) |
