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33 Cards in this Set

  • Front
  • Back
The ANS contains 3 divisions
1. SNS (thoracolumbar)
2. PNS (craniosacral)
3. ENS
Preganglionic neurons have cell bodies?
in the CNS, either brain or spinal cord
Postganglionic neurons have cell bodies in?
the peripheral ganglia
Compare the ganglia location in PNS and SNS?
PNS: ganglia located close to the organ innervated.

SNS: ganglia located far to the organ innervated, lie in the paravertebral ganglia
Are the postganglionic fibers in the PNS short/long?
Short because cell bodies are located close to the organs that they innervate.
Are the postganglionic fibers in the SNS short/long?
Long because the ganglia are farther away from the organ.
Which nervous system (PNS or SNS) has more specificity? Divergence?
PNS: more specificity
SNS: more divergence
What are the 2 types of afferent input to the ANS?
1. Input identical to somatic NS (effects both somatic and ANS)

2. Input specific to autonomic sysstem (no information fed to somatic NS)
All preganglionic neurons (both sympathetic and parasympthatic) release?
Ach
Postganglionic parasympathetic neurons release?

Most postganglionic sympathetic neurons release?
Ach


NE
Exception, sympathetic neurons in sweat glands release?
Ach
What is the endocrine gland closely related to the SNS?
Adrenal medulla
The Cromaffin cells of the adrenal medulla are innervated by what NS?

What are their embryonic origin?

Purpose?
Sympathetic preganglionic neurons

Embryonic origin same as postganglionic neurons

They are endocrine cells so they release hormones into circulation
How are the Cromaffin cells activated?
Ach is released from the preganglionic neurons. As a result, Cromaffin cells release the hormones NE and Epi into the blood stream.
What is the receptor for postganglionic nerve bodies in both the SNS and PNS?
nicotinic cholinergic receptors (Nnerve)

They are cation channel signaling pathways
What are the effector tissue receptors in the PNS called?
muscarinic cholinergic receptors
What are the 5 subtypes for the muscarinic cholinergic receptors?
1. For the odd numbered subtypes, M1, M3, M5-->Gq/PLC pathway

2. For the even numbered subtypes, M2 and M4-->Gi/cAMP -
NE/Epi effector tissue receptors
1. Alpha 1 adrenergic receptors: Via Gq/PLC (vascular smooth m)

2. Alpha 2: Via Gi/cAMP - (Postganglionic SNS endings)

3. B1: Via Gs/cAMP (cardiac cells)

4. B2: Via Gs/cAMP (vascular smooth m)

5. B3: Via Gs/cAMP (fat cells)
Examples of other neurotransmitters besides NE and Ach. There can be co-transmitters & co-localization.
1. Nitric oxide
2. Neuropeptide Y
3. Vasoactive Intetinal Peptide (VIP)
4. ATP
Some autonomic nerves that release neither NE nor Ach
NANC: non-adrenergic, non-cholinergic

They relaee substance P and vasoactive intestinal peptide (VIP)
ANS initation potential
ANS usually not needed to initiate activity

ANS increases/decreaes activity of an effector tissue relative to its intrinsic level.
Dual innervation
When many effector tissues are innervated by both the SNS and PNS
Dual reciprocal innervation
When SNS and PNS may have opposing actions
(ex: SNS acts to increase heart rate & PNS acts to decreaes heart rate)
Axon reflex
-Not really ANS
-injury-->afferent information to SC
-collateral axon branches from main fiber & go into blood vessles and release neurotransmitters into blood
Example of a reflex that is coordinated in the autonomic ganglia (CNS is NOT involved)
Ex: Peristalsis where contraction of circular smooth muscle upstream and contraction of longitudinal muscle downstream
Examples of reflexes that are coordinated in the spinal cord and involve the targets of ANS.
Micturition
Defecation
Ejaculation
Erection
Micturition reflex (urination)
Distention of the urinary bladder-->stretch receptors activated-->Sensory nerves to SC-->Parasympathetic nerves-->contraction of bladder & relaxation of sphincter
Examples of reflexes controlled in the medulla oblongata
1. Swallowing
2. Vomiting
3. Blood pressure regulation
4. Respiration
5. Pupillary reflexes
Blood pressure regulation
Increased BP-->stretch receptors in blood vessles-->info travels to sensory nerves in medulla oblongata-->parasympathetic nerves stimulated-->decreases heart rate
What is the most important ANS structure for afferent input in the medulla?
Nucleus tractus solitarius NTS
Examples of reflexes coordinated in the hypothalamus
1. Temperature regulation
2. Eating & drinking
3. Cardiovascular functions
4. Fight or flight response
Temperature regulation
Increased hypothalamus temperature-->stimulate sympathetic nerves-->sweat gland activation
Examples of cerebral cortical (cortex) control of ANS function
1. Fear or panic-->stimulate fight or flight response
Activates sympathetic nerves and inhibits parasympathetic nerves

2. Emotional stress-->fainting (syncope)
Inhibition of sympathetic nerves
Discharge of Parasympathetic nerves

3. Inhibition of micturition reflex via inhibition of parasympthetic nerves

4. Cognitive activity-->initiate sexual arousal via cerebral cortex
Discharge of sympathetic and parasymapthtic nerves