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33 Cards in this Set
- Front
- Back
The ANS contains 3 divisions
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1. SNS (thoracolumbar)
2. PNS (craniosacral) 3. ENS |
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Preganglionic neurons have cell bodies?
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in the CNS, either brain or spinal cord
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Postganglionic neurons have cell bodies in?
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the peripheral ganglia
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Compare the ganglia location in PNS and SNS?
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PNS: ganglia located close to the organ innervated.
SNS: ganglia located far to the organ innervated, lie in the paravertebral ganglia |
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Are the postganglionic fibers in the PNS short/long?
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Short because cell bodies are located close to the organs that they innervate.
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Are the postganglionic fibers in the SNS short/long?
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Long because the ganglia are farther away from the organ.
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Which nervous system (PNS or SNS) has more specificity? Divergence?
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PNS: more specificity
SNS: more divergence |
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What are the 2 types of afferent input to the ANS?
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1. Input identical to somatic NS (effects both somatic and ANS)
2. Input specific to autonomic sysstem (no information fed to somatic NS) |
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All preganglionic neurons (both sympathetic and parasympthatic) release?
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Ach
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Postganglionic parasympathetic neurons release?
Most postganglionic sympathetic neurons release? |
Ach
NE |
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Exception, sympathetic neurons in sweat glands release?
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Ach
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What is the endocrine gland closely related to the SNS?
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Adrenal medulla
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The Cromaffin cells of the adrenal medulla are innervated by what NS?
What are their embryonic origin? Purpose? |
Sympathetic preganglionic neurons
Embryonic origin same as postganglionic neurons They are endocrine cells so they release hormones into circulation |
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How are the Cromaffin cells activated?
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Ach is released from the preganglionic neurons. As a result, Cromaffin cells release the hormones NE and Epi into the blood stream.
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What is the receptor for postganglionic nerve bodies in both the SNS and PNS?
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nicotinic cholinergic receptors (Nnerve)
They are cation channel signaling pathways |
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What are the effector tissue receptors in the PNS called?
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muscarinic cholinergic receptors
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What are the 5 subtypes for the muscarinic cholinergic receptors?
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1. For the odd numbered subtypes, M1, M3, M5-->Gq/PLC pathway
2. For the even numbered subtypes, M2 and M4-->Gi/cAMP - |
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NE/Epi effector tissue receptors
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1. Alpha 1 adrenergic receptors: Via Gq/PLC (vascular smooth m)
2. Alpha 2: Via Gi/cAMP - (Postganglionic SNS endings) 3. B1: Via Gs/cAMP (cardiac cells) 4. B2: Via Gs/cAMP (vascular smooth m) 5. B3: Via Gs/cAMP (fat cells) |
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Examples of other neurotransmitters besides NE and Ach. There can be co-transmitters & co-localization.
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1. Nitric oxide
2. Neuropeptide Y 3. Vasoactive Intetinal Peptide (VIP) 4. ATP |
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Some autonomic nerves that release neither NE nor Ach
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NANC: non-adrenergic, non-cholinergic
They relaee substance P and vasoactive intestinal peptide (VIP) |
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ANS initation potential
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ANS usually not needed to initiate activity
ANS increases/decreaes activity of an effector tissue relative to its intrinsic level. |
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Dual innervation
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When many effector tissues are innervated by both the SNS and PNS
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Dual reciprocal innervation
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When SNS and PNS may have opposing actions
(ex: SNS acts to increase heart rate & PNS acts to decreaes heart rate) |
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Axon reflex
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-Not really ANS
-injury-->afferent information to SC -collateral axon branches from main fiber & go into blood vessles and release neurotransmitters into blood |
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Example of a reflex that is coordinated in the autonomic ganglia (CNS is NOT involved)
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Ex: Peristalsis where contraction of circular smooth muscle upstream and contraction of longitudinal muscle downstream
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Examples of reflexes that are coordinated in the spinal cord and involve the targets of ANS.
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Micturition
Defecation Ejaculation Erection |
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Micturition reflex (urination)
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Distention of the urinary bladder-->stretch receptors activated-->Sensory nerves to SC-->Parasympathetic nerves-->contraction of bladder & relaxation of sphincter
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Examples of reflexes controlled in the medulla oblongata
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1. Swallowing
2. Vomiting 3. Blood pressure regulation 4. Respiration 5. Pupillary reflexes |
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Blood pressure regulation
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Increased BP-->stretch receptors in blood vessles-->info travels to sensory nerves in medulla oblongata-->parasympathetic nerves stimulated-->decreases heart rate
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What is the most important ANS structure for afferent input in the medulla?
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Nucleus tractus solitarius NTS
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Examples of reflexes coordinated in the hypothalamus
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1. Temperature regulation
2. Eating & drinking 3. Cardiovascular functions 4. Fight or flight response |
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Temperature regulation
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Increased hypothalamus temperature-->stimulate sympathetic nerves-->sweat gland activation
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Examples of cerebral cortical (cortex) control of ANS function
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1. Fear or panic-->stimulate fight or flight response
Activates sympathetic nerves and inhibits parasympathetic nerves 2. Emotional stress-->fainting (syncope) Inhibition of sympathetic nerves Discharge of Parasympathetic nerves 3. Inhibition of micturition reflex via inhibition of parasympthetic nerves 4. Cognitive activity-->initiate sexual arousal via cerebral cortex Discharge of sympathetic and parasymapthtic nerves |