Pharmacology Test 1B

Front 1

Which of the following routes bypasses the drug absorption phase?

Back 1

Intravenous

Front 2

Most drugs are absorbed in the intestine by which of the following processes?

Back 2

Passive non-ionic diffusion

Front 3

All of the following help determine the rate and extent of drug absorption EXCEPT

Back 3

Potency

Front 4

Bioavailability (Foral) is?

Back 4

The fraction of a drug's dose that is absorbed

Front 5

Which of the following organs is a drug perfused least rapidly?

Back 5

Adipose Tissue

Front 6

In the mythical 70 kg man, a drug that is distributed into total body water has an approximate Vd of ?

Back 6

40 L

Front 7

Probenicid blocks secretion of penicillin from kidney tubules into urine. If a px on penicillin is subsequently given probenicid, which changes would occur in penicillin?

Back 7

Decreased Cl

Probenicid is a substrate for Weak Organic Acid (WOA) Transporters. Its administration inhibits secretion of many drugs.

Front 8

Phase I metabolism of drugs may involve all EXCEPT?

Back 8

Conjugation with a hydrophilic substance

Front 9

Metabolism of active drug may do any EXCEPT?

Back 9

Decrease the drug Vd

Front 10

Drugs which are very rapidly metabolized by the liver most likely exhibit?

Back 10

Poor bioavailability

Front 11

Which of the following is the least important property of drug?

Back 11

Potency

Front 12

The therapeutic index of a drug measures?

Back 12

Potency of therapeutic effect vs potency of toxic effect

Front 13

Induction of drug metabolism may result in all EXCEPT?

Back 13

Decreased Vd

Front 14

14. Compared to its density (# per cell) at the resting state, the density of a B-adrenergic receptor on vascular smooth muscle will likely?

Back 14

Decrease during chronic administration of agonist

Front 15

Log Dose-Response Curve for drug action obeys the Law of Mass Action. The following about this relationship are correct for graded log-dose-response curve EXCEPT

Back 15

“effect” may refer to the range of a physiological responses with a group of individuals to a given dose of drug

Front 16

T1/2 = ?

Back 16

Vd/Cl

Front 17

Which of the following is most important factor in determining the absorption of a drug?

Back 17

Concentration of uncharged form in the intestine

Front 18

Drug A has very short T ½. Of the following, which is most compatible with a short T ½?

Back 18

Extensive first pass metabolism

Front 19

Drug A inhibits the biotransformation of B. If B is active form, coadministration of A will have what effect on B?

Back 19

Shortens its duration of action

Front 20

Which of the following properties of a drug is most closely associated with its ability to cross blood-brain barrier?

Back 20

Lipid Solubility

Front 21

Drug that is highly charged and very water soluble is likely to display which of the following:?

Back 21

Low Foral

Front 22

A drug that can have all of the following properties with regard to receptors EXCEPT?

Back 22

Cause up-regulation of a receptor if it is an agonist of that receptor

Front 23

All of the following regarding kidney handling of drugs are correct EXCEPT

Back 23

Lipid soluble drugs are reabsorbed by specific active transport systems

Front 24

Drug X is metabolized in liver by P450 to an inactive compound. Drug Z is then added to px regime. Drug Z induces metabolism of Drug X by P450. 2 weeks after Z begins, which statement comparing to BEFORE Z begins is correct?

Back 24

Blood levels of X are decreased

Front 25

Hepatic first pass metabolism of drugs is most significant after which route?

Back 25

Oral

Front 26

All are true of P450 reactions EXCEPT?

Back 26

Utilize ATP as substrate

Front 27

Formation of acetaminophen glucuronide is described by each of the following EXCEPT

Back 27

Its necessary for further acetaminophen metabolism by P450

Front 28

step reaction Codeine --> Morphine --> Morphine-O-sulfate is characterized by which?

Back 28

BOTH Metabolic drug activation and formation of water soluble metabolite

Front 29

An agonist is a chemical substance that?

Back 29

Binds to a specific receptor and initiates a response

Front 30

Which of the following statements best describes the toxicity of most drugs?

Back 30

Toxicity is often an extension of desired effect

Front 31

Which statement concerning a drug's properties is Correct?

Back 31

The effects of a competitive antagonist are reversible

Front 32

Classification of hormone and neurotransmitter receptors into different groups is predominately done by measurement of?

Back 32

Rank order of potency of a series of agonists and antagonists

Front 33

Drug with Vd of 500 is likely?

Back 33

Primarily in muscle and fat

Front 34

Which is a correct statement about pharmacokinetic or pharmacodynamic parameters?

Back 34

Cl is the constant fraction of a drug cleared per unit time

Front 35

All statements are correct about drug distribution Except?

Back 35

The rate of movement of water soluble drugs across capillaries is directly proportional to the number of capillary transport systems for that drug

Front 36

A collection of drugs binds to receptor X. 99% of X is in the inactive state in absence of agonist. Which statement concerning properties of drugs is Correct?

Back 36

Partial agonists will activate the receptor more than inverse agonist

Front 37

Which would NOT delay the metabolic transformation of a drug?

Back 37

Receptor desensitization

Front 38

Thiopental is very lipid soluble. Which contributes to the short duration of anesthetic action of a single dose of thiopental?

Back 38

Rapid accumulation in fat

Front 39

Hepatic blood flow and intrinsic hepatic clearance (Metabolism) are important factors in clearance of drugs with which properties?

Back 39

Extensive reabsorption in kidney