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11 Cards in this Set
- Front
- Back
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Inflammation |
chronic inflammation may eventually lead to disease/conditions (cancer, rheumatoid arthritis) Infl. response mediated by histamine, serotonin, bradykinin, leukotrienes, and prostaglandins Last two have a major influence on inflammation symptoms |
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Gout |
caused by overproduction of uric acid or decreased uric acid secretion (or both). Too much uric acid cause uric acid crystals to deposit in joints/tissues causing inflammation and extreme pain |
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NSAIDs |
antipyretic, anti-inflammatory, analgesic properties ASA- inhibit platelet aggregation (MI protection) MOA: inhibit the 2 pathways NSAIDs block COX enzyme ASA- only NSAID that has antiplatelet effects
Indications: antipyretic, antiinflammatory, analgesic (give tylenol ONLY to children, do NOT give ASA) ASA- platelet aggregation prevention (MI, stroke) Arthritis- rheumatoid, osteoarthritis
CI: do NOT use in children w/ viral illness/ flulike symptoms-> Reye's syndrome (life-threatening, neurological deficits), VK deficiency/peptic ulcer disease, pregnancy 3rd trimester, increases bleeding potential
AE: GI- mild heartburn to severe GI bleeding (N&V). Acute renal failure- common in dehydrated patients, poor renal fx, taking diuretics. Interactions- anticoagulants, corticosteroids, diuretics |
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Misoprostol |
(Cytotec), given w/ NSAIDs to help prevent GI bleeding/ulcers |
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NSAID OD Management |
adults- see tinnitus, hearing loss children- hyperventilation, CNS effects (dizziness, drowsiness, behavioral changes Given activated charcoal |
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Aspirin |
ASA, salicylate, daily use 81mg or 325 mg, for prophylaxis of stroke, MI risks in adults; prevention of thrombotic events |
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Indomethacin |
(Indocin), used for arthritis, promote closure of ductus arteriosus and used for preterm labor Acetic Acid Derivative |
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Ketorlac |
Toradol, powerful analgesic effects (used post-op for moderate to severe acute pain control via IV push). Think of this like a "big" Motrin. Can use for up to 5 days Acetic Acid Derivative |
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Ibuprofen |
(Motrin, Advil): prototype NSAID. Analgesic, arthritis, antipyretic Proponis acid derivative |
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Antigout Drugs |
Used to decrease symptoms of acute gout attack, prevent future gout attacks Reduces uric acid levels in body MOA: reduce production of uric acid by inhibiting enzyme called xanthine oxidase, responsible for converting purines into uric acid |
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Allopurinol |
(Zyloprim): inhibits xanthine oxidase. For pts with excessive uric acid production. |
