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14 Cards in this Set
- Front
- Back
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Gout |
An inflammatory condition that attacks joints, tendons, and other tissues caused by an overproduction of uric acid or decreased uric acid or both |
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Hyperuricemia |
An excess of uric acid |
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Colchine |
Inhibits the migration of leukocytes to the inflamed site. Does not inhibit uric acid synthesis or promote uric acid secretion
Effective in alleviating acute symptoms of gout but not in decreasing inflammation in other sites
A short term therapy |
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What is the most common location for gout? |
Big toe |
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What are the contraindications and risks of colchicine? |
Should not be used if the patient has a severe renal, cardiac, or GI problem Can cause leukopenia |
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Allopurinol |
A uric acid inhibitor: inhibits the final steps of the uric acid biosynthesis and therefore lowers serum uric acid levels Prophylactic therapy used to prevent gout |
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Considerations for allopurinol |
- Highly protein bound (beware of warfarin) - Patients should increase fluid intake - Patients should avoid alcohol, caffeine, and thiazide diuretics - Risk of exfoliate dermatitis/Steven Johnson syndrome - Patient should have yearly eye exam due to risk of vision changes |
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Probenecid |
A uricosuric: increases the rate of uric acid secretion by inhibiting its reabsorption Effective in alleviating chronic gout but should but be used in an acute attack Often used with colchicine to manage gout |
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Considerations for probenecid |
Highly protein bound Give with food or antacids |
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General side effects of antigout medications |
- Anorexia/Nausea/Vomiting/Diarrhea - Stomatitis - Dizziness - Rash - Pruritis - Metallic taste |
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Stomatitis |
Inflammation and sores in the mouth |
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Pre-administration assessment for antigout drugs? |
- determine if history of gastric, renal, cardiac, or liver disorders - asses serum uric acid levels - check BUN and creatinine levels to monitor renal functioning and alkaline phosphatase levels to monitor hepatic functioning |
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Post-administration assessment/considerations for antigout drugs |
Assess for presence of GI symptoms Assess urine output Push fluids |
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Teaching points for antigout drugs |
- Encourage patient to follow through with doctor appointments and lab tests - Patient should drink plenty of fluids - Watch for side effects & A/N/V/D, GI upset, rash, pruritis, metallic taste in mouth, dizziness |
