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21 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Omeprazole |
Hydrogen pump inhibitor at gastric parietal cells; anti secretory; blocks final step of acid production |
Acid unstable; enteric coated; oral administration |
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Aspirin |
1) Analgesic and anti rheumatic; 2) antipyretic; 3) anti platelet; 4) anti-inflammatory |
Oral or rectal administration; enteric coated; high dose elimination is zero order 1) By inhibition of prostaglandin synthesis 3) Inhibition of thromboxane A2 (when given at low dose) |
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Heparin |
Anti coagulant |
Poorly absorbed from GI trac; IV or subcutaneous administration Mechanism: Inhibits thrombus and clot formation by blocking prothrombin to thrombin and fibrinogen to fibrin conversion. |
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Insulin |
Antidiabetic, hormone |
Unstable in the GI tract; IV or subcutaneous administration Mechanism: Promotes storage of the body's fuels and facilitates transport of metabolites and ions (K+) through cell membrane |
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Rocuronium |
Neuromuscular blocker |
IV administration |
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Chlorpromazine |
Antihistamine |
Competitively blocks effects of histamine at H1 receptor sites. Has atropine-like antipruritic (anti-itch) and sedative effects. |
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Clonazepam |
Anti epileptic, benzodiapine |
Benzodiapines potentiate effect of GABA (an inhibitory neurotransmitter) |
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Phenytoin |
Anti epileptic without general CNS depression |
Stabilises neural membranes and prevents hyperexcitability caused by excessive stimulation; limits spread of seizure activity from an active focus; for treating cardiac arrhythmia esp those induced by digitalis; arrhythmic props very similar to licodaine's |
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Clopidogrel |
Antiplatlet, ADP receptor antagonist |
Inhibits platelet aggregation by blocking ADP receptors on platelets, preventing clumping of platelets. |
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Codeine |
Narcotic agonist analgesic, antitussive (relieves cough) |
Acts at opioid receptors on CNS to produce analgesia, euphoria and sedation. Acts in medullary cough centers to depress cough reflex |
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Phenobarbital |
Barbiturate (long acting), sedative, hypnotic, anticonvulsant, anti epileptic |
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Rifampin |
Anti tuberculosis |
Reduces plasma conc of HIV proteases inhibitor leading to its ability to suppress HIV replication |
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Carbamazepine |
Anti epileptic |
Mechanism not understood. May be related to its ability to inhibit polysynaptic responses and block post tetanic potentiation. Is chemically related to tricyclic antidepressants (TCAs) |
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Ketoconazole |
Inhibits rxn for which it is not a substrate |
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Omeprazole |
Potent inhibitor of 3 CYP isozymes for warfarin metabolism. Leads to increased anticoagulant effect causing risk of bleeding |
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Erythromycin |
Macrolide antibiotic |
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Ritonavir |
Anti retroviral medication |
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Nifedipine |
Ca2+ channel blocker, anti anginal agent, antihypertensive |
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Clarithromycin |
Macrolide antibiotic |
Inhibits protein synthesis |
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Simvastatin |
Antihyperlipidemic, HMG CoA inhibitor |
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Grapefruit juice |
Inhibits CYP3A4, which metabolises nifedipine, clarithromycin and simavastatin |
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