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23 Cards in this Set
- Front
- Back
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How do NSAIDs work? |
NSAIDs inhibit prostaglandin cyclooxygenase and thus inhibit production of prostaglandins |
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What are two "good" functions of prostaglandins? |
secretion of mucus in the stomach and renal vasodilation |
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Cyclooxugenase 1 (COX-1) stimulates what? |
the production of mucous lining of the stomach |
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Cyclooxygenase 2 (COX-2) stimulates what? |
inflammatory response |
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Aspirin = ________________ ___________ = __ __ __ |
Acetylsalicylic Aci, ASA |
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___________ is the oldest NSAID and is not effective for treatment of dysmenorhhea. |
Aspirin |
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Because Aspirin is an effective inhibitor of _____________________ ___, it is used for reducing risk of MI's due to its ability to inhibit platelet aggregation |
thromboxane A2 |
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What is a unique adverse effect of Aspirin? |
increased risk of Reye's syndrome in children |
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What are two trade names for ibuprofen? |
Advil, Motrin |
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What is the advantage of naproxen (Aleve) over other NSAIDs? |
once a day formula |
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What is the most efficacious NSAID which also has the highest incidence of stomach ulceration? |
ketorolac |
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Which NSAID is primarily used to treat gout attacks? |
indomethacin (Indocin) |
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Which specific COX-2 inhibitor is still on the market? |
Celebrex |
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Is acetaminophen an NSAID? Why or why not? |
No. It is an analgesic and antipyretic but not an anti-inflammatory |
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What is the main advantage of acetaminophen over OTC NSAIDs? |
It does not cause stomach ulcerations |
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What is the treatment for acetaminophen overdose? |
acetylcysteine (Mucomyst) |
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How does methotrexate treat RA? |
Methotrexate acts as an antagonist of folic acid, which is essential for DNA and RNA synthesis. |
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What are three side effects of steroid use in treating RA? |
edema (especially facial), delayed wound healing, osteoporosis |
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What are the two most common treatment for RA? |
Enbrel and Humira |
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How do Enbrel and Humira work? |
Enbrel and Humira are both antibodies that bind to inhibit tumor necrosis factor (TNF) |
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What is the injectable RA treatment? |
Enbrel and Humira |
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What is the most common triptan? |
sumatriptan (Imitrex) |
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How does the triptan family of drugs treat migraines? |
The triptan family of drugs has a structure similar to serotonin and act as serotonin agonists ultimately inhibiting inflammatory molecules |
