Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Steps of Inflammation
|
1-Vasodilation
2-Vascular permeability (Edema) 3-Cellular infiltration (Pus) 4-Thrombosis (Clots) 5-Stimulation of nerve endings (Pain) |
|
|
Cyclooxygenase-1
|
Location-Present in all tissues
Fxn's-Protects gastric mucosa, supports kidney fxn, promotes platelet aggregation Inhibition by med's-Undesirable: increase risk of gastric bleeding and kidney failure Inhibition of COX-1 causes bleeding, gastric upset and decreased renal fxn. |
|
|
Cyclooxygenase-2
|
Location-Present at sites of tissue injury
Fxn's-Mediates inflam, sensitizes pain receptors, mediates fever in the brain Inhib. by med's-Desirable: results in suppression of inflam Inhibition of COX-2 results in inflam suppression |
|
|
Histamine
|
Initiates inflam response
Key mediator in inflam Stimulates pain receptor |
|
|
H1 receptors
|
In vascular smooth muscle, in bronchi.
Stimulation causes inflam response |
|
|
H2-receptors
|
In stomach
Stimulates HCl |
|
|
NSAID's
-Prototype- |
ibuprofen (Advil, Motrin)
MOA: inhibit prostaglandin synthesis PU: for musculoskeletal d/o's (RA, OA), mild to moderate pain, reduce fever, 1y dysmennorheal pain AE: nausea, heartburn, epigastric pain, dizziness |
|
|
Glucocorticoid
-Prototype- |
prednisone (Meticorten)
MOA: metabolized to an active glucocorticoid PU: treat inflam AE: long term -> Cushing snd |
|
|
Antipyretics -P-
|
acetaminophen (Tylenol)
MOA: reduce fever at hypothalamus and dilate peripheral blood vessels (enables sweating and dissipates heat), doesn't affect blood coagulation PU: relieve pain and fever AE: liver damage, causes less GI irritation than aspirin |
