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19 Cards in this Set
- Front
- Back
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Half-Life
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t(1/2) = (0.7 x Vd) / CL
* If given Vd with unit of L/kg, you need to multiply the Vd x the patients wt in kg to get Liter units |
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Volume of Distribution
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Vd = amount in body / plasma drug conc.
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Loading Dose
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LD = Css x Vd
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Maintenance Dose
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MD = CSS x CL
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Define zero order elimination
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Constant AMOUNT eliminated
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What are the three examples of zero order drugs?
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PEA: Phenytoin, Ethanol, Aspirin
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Define first order elimination
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Constant PROPORTION eliminated
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Theraputic Index Equation
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TI : LD50 (median lethal dose) / ED50 (median effective dose)
*TILE: TI = L/E |
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Which is safer, a high TI or low TI?
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High, means either a higher dose needed for lethality, or a lower effective dose
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Define Efficacy
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Max effect of drug
EX: pain medications |
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What else is efficacy known as?
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Vmax
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Define Potency
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Amount of drug needed for effect
INC Potency = INC affinity for receptor |
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What else is potency known as?
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Km
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How does a competitive antagonist shift the curve?
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Moves it to the right
INC Km, DEC potency, No change to efficacy |
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How can a competitive antagonist be overcome?
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By increasing the concentration of agonist substrate
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How does a noncompetitive antagonist shift the curve?
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Shifts it down
DEC efficacy, DEC Vmax |
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Can a noncompetitive antagonist be overcome?
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No, it is irreversible
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How does a partial agonist shift the curve?
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Shifts it down
DEC efficacy |
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What does a partial agonist do to potency?
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Potency is an independent variable in this situation, it can be shifted up or down
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