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14 Cards in this Set
- Front
- Back
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The process by which the drug exerts its effect is known as ...
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mechanism of action
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What is the location on a cell surface where drugs and enzymes interact with cellular components, called?
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receptor
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What does the pharmaceutial phase consist of?
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-Disentigration of dosage form
-Dissolution of drug |
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What does the Pharmocokinetic phase consist of?
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-Absorption
-Distribution -Metabolism -Excretion |
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What does the pharmacodynamic phase consist of?
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Drug-Receptor Interaction
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What are some characteristics of drug receptor binding?
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its...
-reversible -selective -graded -agonistic or antagonistic |
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DRUGS that are AGONISTIC have....
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a high affinity for the receptor and produce a pharmacologic response
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AGENTS that are ANTAGONISTIC have....
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an affinity for a receptor (or area near receptor) that counteracts action of drug or other substances at the receptor
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There are also NONCOMPETITIVE antagonistic drugs that...
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get in the way of the receptor so the drug or substance is unable to bind.
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The process by which a drug goes into the solution and becomes available for absorption is known as...
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Dissolution
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The concentration of a drug is influenced by what 4 factors..
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the rate and extent to which a drug is...
-absorbed by the body -distributed to the site of action -biotrandformed or metabolized -excreted from the body |
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What variables influence how a drug is absorbed, distributed, metabolized and excreted?
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-molecular size
-degree of water/lipid solubility -electrical charge of drug |
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Whats easier to cross a membrane? Ionized or Nonionized drugs
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non-ionized, cuz its lipid soluble
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Whats hard to cross a membrane? Ionized or Nonionized drugs?
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Ionized, cuz its water soluble, which makes it hard to pass through lipids.
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