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32 Cards in this Set

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  • Back
True or False: dietary iron absorption is highly regulated
True
What is the average absorption of iron in an adult?
1mg/day
What is the rate of absorption of iron in women between puberty and menopause?
2mg/day
What increases iron absorption? Hint: there are 5
heme iron
ethanol comsumption
excessive consumption of ascrobic acid
cigarette smoking
hemochromatosis
Are sweat, tears, and sloughing of intestinal mucosa a major or minor route of iron elimination?
minor
What are the potential routes of iron elimination in women between puberty and menopause?
menstruation
fetal growth
lactation
True or False: ingestion of oral contraceptives do not reduce excretion of iron?
Fals: oral contraceptives do reduce iron excretion via menstrual blood
This enterocyte transports iron from the lumen through apical membrane
DMT-1 (divalent metal transporter)
This enterocyte mediates rion efflux through basal membrane
Ferroportin
What regulates ferroportin expression?
Hepsidin
True or False: dietary iron absorption is highly regulated
True
What is the average absorption of iron in an adult?
1mg/day
What is the rate of absorption of iron in women between puberty and menopause?
2mg/day
What increases iron absorption? Hint: there are 5
heme iron
ethanol comsumption
excessive consumption of ascrobic acid
cigarette smoking
hemochromatosis
Are sweat, tears, and sloughing of intestinal mucosa a major or minor route of iron elimination?
minor
This protein transports iron in the blood
tranferrin
How many extracellular domains do the transferrin receptor have?
2
What state does transferrin have to be in to be able to bind iron?
monoferric or diferric state
What protein stores iron?
ferritin
What part of ferritin incorporates iron into the core?
heavy chain
What part of ferritin chelates core iron?
light chain
Above what level does ferritin lose its efficiency to store iron?
1200-1400 iron atoms
how much iron atom can ferritin store?
4200 iron atoms
what iron storing protein is found in the exocrine gland and is excreted durig sweating, crying, lactation, pregnancy, and menstruation?
lactoferrin
In what state does IRP1 have aconitase activity?
4Fe-4S state
In what state does IRP1 bind to IRE?
3Fe-4S state
In what state does IRP2 have aconitase activity?
IRP2 does not have aconitase activity period
When IRP is bound to IRE, is ferritin made?
no
When IRP is bound to IRE, is transferrin made?
yes
When IRP is unbound to IRE, is ferritin made?
yes
When IRP is unbound to IRE, is transferrin made?
no
In malignant cells, is transferrin or ferritin increased?
transferrin