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42 Cards in this Set

  • Front
  • Back
Which of the following is correct?

a. prostanoids are a type of eicosanoid which are a type of autocoid

b. autocoids are a type of eicosanoids which are a type of prostanoids

c. autocoids are a type of prostanoids which are a type of eicosanoid
a. prostanoids are a type of eicosanoids which are a type of autacoids
What am I:
subclass of autacoids
derived from fatty acids that make up the cell membrane
expressed in a cell specific fashion
eicosanoids
eiconasoids are further classifiend into _______ and ________
cyclooxygenase products
lipoxygenase products
What am I:
subclass of eicosanoids
consists of prostaglandins, prostacylines, and throboxanes
same as PGI2
prostanoids
Activation of what enzyme releases arachidonic acid?
phospholipase A2
arachidonic acid is metabolized by cyclooxygenase into what?
prostanoids
arachidonic acis is metabolized by lipoxygenase into what?
HETEs
leukotrienes
lipoxins
True or False: eiconsanoids can bind to neighboring receptors and have different biologic effects
True
Which of the following are not physiological effects of eicosanoids?

uterine tone
blood pressure regulation
inflammation
gastric secretion and motility
platelet aggregation
bronchial tone
effect on kidney
CNS (fever;pain;sleep)
eye
liver
liver
This eicosandoid causes bronchodialation via relaxation of respiratory smooth muscle
PGI2
This eicosanoid inhibits gastric acid secretion and have cytoprotective effects via increase in mucus secretion
PGE2
This eicosanoid causes the uterine muscle to contract
PGF2alpha
This eicosanoid causes uterine muscle to contract during pregnancy
PGE2
This eicosanoid relaxes smooth muscle of the corpora cavernosa (enhance penile erection)
PGE1
This eicosanoid induce fever
PGE2
This eicosanoid induce sleep
PGD2
This eicosanoid induce wakefulnes
PGE2
These eicosanoids sensitize peripheral nervous system to painful stimuli by increasing their terminal membrane excitability
PGE2
PGI2
This eicosanoid lowers intraocular pressure
PGF2alpha
What are the 2 ways prostaglandins differ?
the substituent's of the pentane ring
number of double bonds on side chain
Which of the following drugs are not leukotriene inhibitors?

a. zafirlukast
b. montelukast
c. alprostadil
d. zileuton
alprostadil
Which prostaglandin analogues stimulates uterine contraction resulting in termination of pregnancy?
dinoprostone
misoprostol
carboprost tromethamine
This drug is indicated for the temporary mainenance of patency of ductus arteriosus in neonates with ductal-dependent congential heart disease until surgery can be performed and in erectile dysfunction
alprostadil
What is the box warning for alprostadil?
apnea
This drug causes vasodilation of vascular and ductus arteriosus smooth muscle and relaxes trabecular smooth muscle by dilation of cavernosal arteries
alprostadil
What are the contraindications of alprostadil?
conditions predisposing patients to priaprism
patients with anatomical deformation of the penis
penile implants
pregnancy of the partner
List the following in order of increasing half lives:

epoprostenol
lloprost
treprostenil
epoprostenol 5min
lloprost 30 min
treprostenil 4 hrs
What are epoprostenol, iloprost, and treprostenil indicated for?
pulmonary arterial hypertension
What drugs vasodilate vascular beds decreasing thrombogenesis and platelet clumping in the lungs by inhibiting platelet aggregation?
epoprostenol
iloprost
treprostenil
epoprostenol, iloprost and treprostenil may enhance the toxic effects of these agents
anticoagulants
Which of the following are used for open glaucoma?

latanoprost
bimatoprost
travoprost
iloprost
latanoprost
bimatoprost
travoprost
These drugs reduce intraocular pressure by increasing the outflow of aqueous humor
latanoprost
bimatoprost
travoprost
This drug may increase the percetn and duration of hairs in the growth phase, resulting in eyelash growth
bimatroprost
Dinoprostone is an analogue of what PG?
PGE2
Dinoprostone is indicated for termination of pregnancy during what trimester?
2nd
Carboprost tromethamine is an analogue of what PG?
PGF2 alpha
What trimester of pregnancy is carboprost indicated for?
2nd
During what trimester of pregnancy is misoprostal indicated for?
1st
misoprostal is an analogue of what PG?
PGE1
alprostadil is an analagou of what PG?
PGE1
epoprostenol, iloprost, and treprostenil are analogues of what PG?
PGI1
latanoprost, bimatoprost and travoprost are analogues of what PG?
PGF2 alpha