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42 Cards in this Set
- Front
- Back
Which of the following is correct?
a. prostanoids are a type of eicosanoid which are a type of autocoid b. autocoids are a type of eicosanoids which are a type of prostanoids c. autocoids are a type of prostanoids which are a type of eicosanoid |
a. prostanoids are a type of eicosanoids which are a type of autacoids
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What am I:
subclass of autacoids derived from fatty acids that make up the cell membrane expressed in a cell specific fashion |
eicosanoids
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eiconasoids are further classifiend into _______ and ________
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cyclooxygenase products
lipoxygenase products |
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What am I:
subclass of eicosanoids consists of prostaglandins, prostacylines, and throboxanes same as PGI2 |
prostanoids
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Activation of what enzyme releases arachidonic acid?
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phospholipase A2
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arachidonic acid is metabolized by cyclooxygenase into what?
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prostanoids
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arachidonic acis is metabolized by lipoxygenase into what?
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HETEs
leukotrienes lipoxins |
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True or False: eiconsanoids can bind to neighboring receptors and have different biologic effects
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True
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Which of the following are not physiological effects of eicosanoids?
uterine tone blood pressure regulation inflammation gastric secretion and motility platelet aggregation bronchial tone effect on kidney CNS (fever;pain;sleep) eye liver |
liver
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This eicosandoid causes bronchodialation via relaxation of respiratory smooth muscle
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PGI2
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This eicosanoid inhibits gastric acid secretion and have cytoprotective effects via increase in mucus secretion
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PGE2
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This eicosanoid causes the uterine muscle to contract
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PGF2alpha
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This eicosanoid causes uterine muscle to contract during pregnancy
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PGE2
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This eicosanoid relaxes smooth muscle of the corpora cavernosa (enhance penile erection)
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PGE1
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This eicosanoid induce fever
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PGE2
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This eicosanoid induce sleep
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PGD2
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This eicosanoid induce wakefulnes
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PGE2
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These eicosanoids sensitize peripheral nervous system to painful stimuli by increasing their terminal membrane excitability
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PGE2
PGI2 |
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This eicosanoid lowers intraocular pressure
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PGF2alpha
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What are the 2 ways prostaglandins differ?
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the substituent's of the pentane ring
number of double bonds on side chain |
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Which of the following drugs are not leukotriene inhibitors?
a. zafirlukast b. montelukast c. alprostadil d. zileuton |
alprostadil
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Which prostaglandin analogues stimulates uterine contraction resulting in termination of pregnancy?
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dinoprostone
misoprostol carboprost tromethamine |
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This drug is indicated for the temporary mainenance of patency of ductus arteriosus in neonates with ductal-dependent congential heart disease until surgery can be performed and in erectile dysfunction
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alprostadil
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What is the box warning for alprostadil?
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apnea
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This drug causes vasodilation of vascular and ductus arteriosus smooth muscle and relaxes trabecular smooth muscle by dilation of cavernosal arteries
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alprostadil
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What are the contraindications of alprostadil?
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conditions predisposing patients to priaprism
patients with anatomical deformation of the penis penile implants pregnancy of the partner |
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List the following in order of increasing half lives:
epoprostenol lloprost treprostenil |
epoprostenol 5min
lloprost 30 min treprostenil 4 hrs |
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What are epoprostenol, iloprost, and treprostenil indicated for?
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pulmonary arterial hypertension
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What drugs vasodilate vascular beds decreasing thrombogenesis and platelet clumping in the lungs by inhibiting platelet aggregation?
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epoprostenol
iloprost treprostenil |
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epoprostenol, iloprost and treprostenil may enhance the toxic effects of these agents
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anticoagulants
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Which of the following are used for open glaucoma?
latanoprost bimatoprost travoprost iloprost |
latanoprost
bimatoprost travoprost |
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These drugs reduce intraocular pressure by increasing the outflow of aqueous humor
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latanoprost
bimatoprost travoprost |
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This drug may increase the percetn and duration of hairs in the growth phase, resulting in eyelash growth
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bimatroprost
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Dinoprostone is an analogue of what PG?
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PGE2
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Dinoprostone is indicated for termination of pregnancy during what trimester?
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2nd
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Carboprost tromethamine is an analogue of what PG?
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PGF2 alpha
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What trimester of pregnancy is carboprost indicated for?
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2nd
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During what trimester of pregnancy is misoprostal indicated for?
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1st
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misoprostal is an analogue of what PG?
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PGE1
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alprostadil is an analagou of what PG?
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PGE1
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epoprostenol, iloprost, and treprostenil are analogues of what PG?
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PGI1
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latanoprost, bimatoprost and travoprost are analogues of what PG?
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PGF2 alpha
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