Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
This hormone increases the amount of glucose in the blood when it is needed. Located in the liver
|
glucagon
|
|
this hormone suppress both glucagon and insulin when needed
|
somatostatin
|
|
What is responsible for secreting?
|
beta cells of the pancreas
|
|
What is the only cell that do not need insulin to allow glucose to enter?
|
beta cells of the pancreas
|
|
What are the steps involved in insulin secretion?
|
1. glucose enter beta cells
2. ATP is produced phosphorylates (inhibits) potassium channels 3. leads to alteration of membrane potential 4. Calcium channels open 5. Insulin is secreted |
|
What receptor is responsible for glucose uptake in beta cells?
|
glut 2 transporter
|
|
what receptor is responsible for glucose uptake in non-beta cells?
|
glut 4 transporter
|
|
Which are short acting insulin?
|
regular
|
|
which are rapid acting insulin?
|
glutisine
lispro aspart |
|
Which are intermediate acting insulin?
|
NPH
|
|
Which are long-acting insulin?
|
detemir
glargine |
|
What am I:
Because of fatty acid tail, can bind to albumin slowly released from albumin to maintain constant level of insulin |
detemir
|
|
What am I:
soluble at pH 4 crystalizes at pH 7.4 When injected into blood, crystals (hexamer) slowly dissovles to maintain contant level of insulin |
glargine
|
|
This type of diabetes is due to insulin resistance or diminished insulin secretion
|
type 2 diabetes
|
|
What drugs are sulfonylureas?
|
glimeperide
glipizide glyburide glidazide |
|
What drugs are meglitinides?
|
repaglinide
nateglinide |
|
What drugs are biguanides?
|
metformin
|
|
What drugs are thiazolidinediones?
|
rosiglitazone
pioglitazone |
|
What drugs are alpha-glucosidase inhibitors?
|
acarbose
meglitol |
|
What drugs are DPP-4 inhibitors?
|
sitagliptin
|
|
What am I:
binds to SUR1 to block potassium channel resulting in insulin release |
sulfonylurea
|
|
What am I:
directly blocks potassium channel resulting in insulin release |
meglitinides
|
|
What am I:
peroxisome proliferator receptor (PPAR) agonist decreases circulating free fatty acids increase expression of circulating adiponectin to increase insulin sensitivity |
thiazolidinediones
|
|
What am I:
GLP-1 and G4P dimer increase insulin release and ecrease glucagon secretion this keeps GLP-1 and G4P bound and active |
DPP-4 inhibitor
|
|
What am I:
competitive reversible inhibitors of pancreatic alpha amylase and membrane bound intestinal alpha-glucosidase hydrolase prevents/decrease enzymatic hydrolysis of starch/carbs in gut |
alpha glucosidase inhibitors
|