Phar 341 - Indirect Acting Sympathomimetic Drugs

Front 1

Define: indirect acting sympathomimetic drugs

Back 1

Drugs that stimulate / replicate the sympathetic nervous system without acting directly on adrenergic/ dopamine receptors (e.g. causing the release of endogenous catecholamines, or inhibits degredation)

Front 2

MOA of amphetamine & methamphetamine?

Back 2

They are indirect sympathomimetic drugs. Work on peripheral by release of catecholamines, but work on CNS though release of biogenic amines (noradrenaline, dopamine, serotonin)

Front 3

MOA of tyramine?

Back 3

Indirect sympathomimetic drug. They are byproducts of tyrosine metabolism (often found in fermented food) that release stored catecholamines (norepinephrine)

Front 4

MOA of ephedrine?

Back 4

Indirect sympathomimetic drug foundin various plants. A direct mixed agonist (a and b) and enhances release of norepinephrine (mild stimulant)

Front 5

MOA of mono amine oxidase inhibitors? (MAO inhibitors)

Back 5

They are indirect sympathomimetic drugs. MAO-A functions in liver. MAO-B causes inhibition (the bad one) Can be used for treatment of parkinsons or depression.

Front 6

MOA of reserpine?

Back 6

Indirect sympathomimetic drug. Inactivation of storage vesicles and nerve terminals, causing inability to store catecholamines, leading to depletion.

Front 7

Therapeutic use of reserpine?

Back 7

1. Initially a antihypertensive, but must be used with diuretic (causes sodium retension) 2. Used in research to differentiate between direct and indirect acting sympathomimetic drugs.

Front 8

Side effects of reserpine?

Back 8

Since it causes catecholamines to deplete, it is very sedating and can cause serious depression.

Front 9

MOA of Guanethidine and Bretylium?

Back 9

They are indirect acting sympathomimetic drugs. They prevent the release of noradrenaline and are used as antihypertensives.