Pathology Ch 11 Study Guide

Front 1

Serum

Back 1

•The fluid remaining after blood clots, differs from plasma in that serum contains no fibrinogen, which was consumed in formation of the clot.

Front 2

Fibrinogen

Back 2

•A protein made by the liver which is a coagulation protein that polymerizes into the meshwork of fibrin in a blood clot.

Front 3

Erythropoietin

Back 3

•A kidney hormone that stimulates erythrocyte production in the bone marrow.

Front 4

Plasma

Back 4

•The liquid part of blood; the term refers to blood circulating in vivo and to anticoagulated blood in vitro.

Front 5

Myeloid

Back 5

•The stem cell that creates:

-Red Cells

-Megakaryocytes

-Monocytes

-Macrophages

-Granulocytes

Front 6

Lymphoid

Back 6

•The stem cell that creates lymphocytes.

Front 7

Granulocytes

Back 7

•Neutrophils

•Eosinophils

•Basophils

Front 8

Platelets

Back 8

•Cytoplasmic fragments of bone marrow platelet-producing cells, megakaryocytes

•One of the cells contained in blood.

Front 9

Macrocytic

Back 9

•In anemia red blood cells may be to large.

Front 10

White Blood Cell Differential Count

Back 10

•Cell count 20-25%

Front 11

Thalassemia

Back 11

•A group of recessive genetic disorders inherited in Mendelian fashion in which hemoglobin is molecularly perfect, but the defect causes a decreased amount of hemoglobin production.

Front 12

Reticulocytes

Back 12

•New red cells which are elevated when red cell production increases as the bone marrow compensates for anemia, red cell destruction, or short red cell life span.

Front 13

Prothrombin Time

Back 13

•Is the time it takes for a sample of patient plasma to clot after the addition of a tissue extract that mimics contact of blood with tissue.

Front 14

Partial Thromboplastin Time

Back 14

•The time it takes for a sample of pateint plasma to clot after addition of compounds that mimics contact of blood with an artificial surface.

-This initiates coagulation via the Intrinsic pathyway and, therefore, the result is abnormal if there are defects in the Intrinsic or common pathyways.

Front 15

Hypochromatic

Back 15

• Iron deficiency anemia

-(RBC small (microcytic) and pale)

Front 16

•Liver

Back 16

•Where does blood cell production occur in a fetus? After Birth?

Front 17

•Totipotent Stem Cell

Back 17

What do all blood cells arise from?

Front 18

Monoblast

(Bone Marrow)

Back 18

•Monocyte

Life span: 1-2Wks

Front 19

Erythroblast

(Bone Marrow)

Back 19

•Red Blood Cells

-Life span: 120 days

Front 20

Megakaryoblast

(Bone Marrow)

Back 20

•Platelets

-Life Span: 1 to 2 days

Front 21

Myeloblast

(Bone Marrow)

Back 21

Granulocytes -Life Span: 4 days

•Neutrophil

•Eosinophil

•Basophil

Front 22

•Lymphoid Stem Cell

- Lymphoblast Cell

(Bone Marrow)

Back 22

•Lymphocyte

-Life Span: 1 to 2 wks

Front 23

•Spleen

Back 23

What body part removes old blood cells from the system?

Front 24

Plasma

Back 24

•7% Proteins - 60% Albumin

•92% Water

•1% Other

Front 25

Hematocrit

Back 25

•99% Red Blood Cells

•1% Leukocytes

-65% Granulocytes

-30% Lyphocytes

-5% Monocytes

Front 26

Laboratory Assessment of blood cells

Back 26

•Red Cell Size (MCV)

-Mean Cell Volume

(HCT divided by RBC)

Front 27

Laboratory Assessment of blood cells

Back 27

•Average hemoglobin content in RBC (MCH)

-Mean cell hemoglobin

(HGB divided by RBC)

Front 28

Laboratory Assessment of blood cells

Back 28

•Hemoglobin concentration / RBC (MCHC)

-Mean cell hemoglobin concentration (HGB divided by HCT)