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50 Cards in this Set
- Front
- Back
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List the gastric antisecretories
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Famotidine
Lansoprazole Omeprazole Pantoprazole Sodium Esomeprazole Magnesium Ranitidine HCL |
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Brand name Famotidine?
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Pepcid
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Brand name Lansoprazole?
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Prevacid
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Brand name Omeprazole?
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Prilosec
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Brand name Pantoprazole Sodium?
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Protonix
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Brand name Esomeprazole Magnesium?
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Nexium
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Brand name Ranitidine HCL?
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Zantac
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Which antisecretories are generic?
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Pantoprazole
Ranitidine Omeprazole Famotidine |
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Indications for Famotidine?
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Tx active duodenal ulcer (short term)
Tx benign gastric ulcers Tx pathological hypersecretory conditions (including severe Zollinger-Ellison Syndrome) Tx GERD (gastroesophageal reflux disease) Simpler: gastric, duodenal, Z-E, GERD Simpler: Ranitidine - errosive esophagitis |
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Indications for Lansoprazole?
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Tx gastric ulcers (short term)
Tx active duodenal ulcer (short term) Tx duodenal ulcers associated with Helicobacter pylori Tx pathological hypersecretory conditions (including Zollinger-Ellison Syndrome) Tx errosive esophagitis (short term) Tx GERD (gastroesophageal reflux disease) |
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Indications for Omeprazole?
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Tx active duodenal ulcer (short term)
Tx errosive esophagitis (short term) Tx pathological hypersecretory conditions (including Zollinger-Ellison Syndrome) Tx GERD Adjunct for tx of Helicobacter pylori infection Simpler: All - gastric |
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Indications for Pantoprazole?
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Tx errosive esophagitis (short term)
Tx pathological hypersecretory conditions (including Zollinger-Ellison Syndrome) Tx GERD Simpler: No gastric or duodenal |
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Indications for Esomeprazole?
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Tx errosive esophagitis (short term)
Tx GERD Adjunct for tx of Helicobacter pylori infection Tx pathological hypersecretory conditions (including Zollinger-Ellison Syndrome) Reduction of gastric ulcers assoc with continuous NSAID therapy |
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Indications for Ranitidine?
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Tx duodenal and gastric ulcers
Tx GERD Tx pathological hypersecretory conditions (including Zollinger-Ellison Syndrome) Tx errosive esophagitis Simpler: All - helicobacter pylori Simpler: Famotidine + errosive esophagitis |
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MoA for Famotidine?
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H2 Rx blocker
Decs acid conc and volume |
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MoA for Lansoprazole?
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PPI (proton pump inhibitor):
Inhibits H+/K+ ATPase (proton pump) in gastric parietal cells |
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MoA for Omeprazole?
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PPI (proton pump inhibitor)
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MoA for Pantoprazole?
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PPI (proton pump inhibitor)
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MoA for Esomeprazole?
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PPI (proton pump inhibitor)
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MoA for Ranitidine?
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H2 Rx blocker
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DIs for Famotidine?
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Decs warfarin clearance
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DIs for Lansoprazole?
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Sucralfate (take lansoprazole 30 mins prior to sucralfate)
Drugs where gastric pH determines BA (eg ketoconazole, ampicillin esters, iron salts, digoxin) Theophylline (may req titration) |
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DIs for Omeprazole?
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Inhibits metab of cilostazole
Inhibits conversion of clopidogrel to its active metabolite Incs plasma levels of diazepam, phenytoin, and warfarin (inhibits their oxidative metabolism) Cyp450 interactions with cyclosporine, disulfiram, benzodiazepines(eg diazepam) Drugs where gastric pH determines BA (eg ketoconazole, ampicillin esters, iron salts, digoxin, cyanocobalamin) Voriconazole may inc plasma levels of omeprazole |
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DIs for Pantoprazole?
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Drugs where gastric pH determines BA
(eg ketoconazole, ampicillin esters, iron salts) |
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DIs for Esomeprazole?
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Esomeprazole inhibits metab of cilostazole
Inhibits conversion of clopidogrel to its active metabolite Incs plasma levels of diazepam Drugs where gastric pH determines BA (eg ketoconazole, ampicillin esters, iron salts, digoxin, cyanocobalamin) Voriconazole may inc plasma levels of esomeprazole Esomeprazole may dec plasma levels of atazanavir |
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DIs for Ranitidine?
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Decs warfarin and lidocaine clearance
May inc absorption of triazolam May dec metab of nifedipine and TCA (tricyclic antidepressants) |
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Contras for Famotidine?
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Renal impairment
If CrCl < 10ml/min dec dose to 20mg Caution during pregnancy (cat B) and lactation |
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Contras for Lansoprazole?
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Pregnancy cat B
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Contras for Omeprazole?
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Animal studies show risk of gastric carcinoid tumors with long term use and very high dosage
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Contras for Pantoprazole?
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Severe hepatic impairment
Rare gastric malignancy(same as the gastric carcinoid tumors of omeprazole?) |
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Contras for Esomeprazole?
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Animal studies show risk of gastric carcinoid tumors with long term use and very high dosage
Rare severe dermatologic rxn (including toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme) |
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Contras for Ranitidine?
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Impaired renal or hepatic
Possible (reversible) hepatitis Caution in pregnancy and nursing Efferdose tabs contain phenylalanine(so contra'd with phenylketonurics) |
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AEs for Famotidine?
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Constipation
Headache Injection site irritation Dizzy Diarrhea |
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AEs for Lansoprazole?
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Headache
Ab pain Nausea Diarrhea |
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AEs for Omeprazole?
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Rare:
Back pain Dizzy Rash Cough Constipation |
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AEs for Pantoprazole?
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Rare:
Diarrhea Rash Headache Flatulence |
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AEs for Esomeprazole?
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Headache
Ab pain Nausea Diarrhea Constipation Flatulence Dry mouth |
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AEs for Ranitidine?
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Constipation
Headache AB PAIN Nausea Dizzy |
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Px for Famotidine?
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Shake well
Discard after 30 days |
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Px for Lansoprazole?
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Take on empty stomach
Can mix delayed release granules in 30ml of water and drink immediately IV must use inline filter |
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Px for Omeprazole?
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Take 30 mins prior to eating
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Px for Pantoprazole?
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nothing special
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Px for Esomeprazole?
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Take at least 60 mins prior to eating
Mix granules with one tablespoon (15ml) of water for 2-3 mins, then drink within 30 mins |
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Px for Ranitidine?
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Dont freeze syrup
Can take with food or milk if GI upset Dissolve effervescent tabs prior to ingestion Complete full course of therapy |
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Dosage forms/strs for Famotidine?
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Tabs 20/40mg
ODT 20/40mg Powder for oral susp 40mg/5ml Premixed injection 20mg/50ml Injection 10mg/ml OTC (non-rx) 10/20mg |
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Dosage forms/strs for Lansoprazole?
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Caps 15/30mg
ODT 15/30mg Delayed release granule for oral susp 15/30mg Powder for injection 20mg/vial |
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Dosage forms/strs for Omeprazole?
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Sustained release caps 10/20/40mg
OTC (non-rx) 20mg |
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Dosage forms/strs for Pantoprazole?
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Delayed release tabs 20/40mg
Granules for oral susp 40mg/packet Powder for injection 40mg/vial |
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Dosage forms/strs for Esomeprazole?
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Delayed release caps 20/40mg
Granules for oral susp 10/20/40mg Powder for injection 20/40mg |
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Dosage forms/strs for Ranitidine?
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Tabs 150/300mg
EFFERdose tabs 25/150mg Syrup 15mg/ml Injection 25mg/ml OTC (non-rx) 75/150mg |
