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25 Cards in this Set
- Front
- Back
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SSRI effect on sleep
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REM suppression
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Clozapine
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- 1-2% develop leukopenia
- No associated with tardive dyskinesia |
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Carbamazepine adverse effects
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- Agranulocytosis, pancytopenia, aplastic anemia
- SIADH |
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TCAs and sedation
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- Most sedating: Amitriptyline, clomipramine, Imipramine, Doxepin
- Mildly sedating: Amoxepine, desipramine, nortriptyline |
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Dopamine agonist
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- Pramipexole
- Ropinerole - Pergolide (concerns about valvular heart disease) |
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Mirtazepine
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- tetracyclic NaSSA.
- Antihistamine at low doses (below 15 mg) - Above 15 mg, induces release of NE, and is not sedating |
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Factors increasing likelihood of seizure in welbutrin use
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- ADHD
- Sleep deprivation - Bulimia - Prior etoh use |
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Vigabatrin
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- Irreversible inhibitor of GABA-T
- Visual field restriction in 30% of users - Toxicity is inner layer of the retina |
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Nefazedone effect on sleep
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- Increases REM sleep time
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Mitoxantrone
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- Antineoplastic agent
- Causes cardiotoxicity (cardiomyopathy) |
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Tolcapone: AE
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- liver failure
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Benztropine and Artane: AE
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- Dry mouth
- Blurred vision - Urinary retention - Confusion (anticholinergic effects, and these are in fact AchR antagonists) |
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ergot DA agonists
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pergolide
bromocriptine |
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non-ergot DA agonists
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Apomorphine
pramipexole ropinerole |
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MAO-B inhibitor
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Seligiline
Resageline |
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COMT inhibitor
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entacapone
tolcapone |
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muscarinic AchR antagonists
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benztropine
trihexyphenidyl |
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NMDA receptor antagonist, anticholinergic
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amantadine
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Sleep: Sedating TCAs
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- REM suppression
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Sleep: Trazadone
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- Increased slow wave sleep, possible REM suppression
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Sleep: SSRIs
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- Increased sleep latency
- Decreased sleep continuity - REM suppression |
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Sleep: Nefazedone
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- No REM suppression
- Preserved sleep architecture - Increased sleep continuity |
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Sleep: Welbutrin
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- Increased REM
- Decreased REM latency |
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Sleep: Mirtazepine
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- Decreased sleep latency, increased sleep time
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Sleep: Antipsychotics
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- Improve sleep efficiency and continuity
- Seroquel increases stage 2 sleep |
