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27 Cards in this Set
- Front
- Back
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Most CNS tumors in adults are (supra/infra) tentorial, while most tumors in children are (supra/infra) tentorial.
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70% of tumors are supratentorial in adults; 70% of tumors are infratentorial in children.
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Oncogenes involved in primary and secondary glioblastoma
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Primary: EGFR; secondary: p53
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Grading for astrocytomas
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"AMEN": Atypia, mitosis, endothelial proliferation, necrosis. 1 criteria-->Grade 2, Atrocytoma. 2 criteria-->Grade 3, Anaplastic astrocytoma; 3 criteria-->Grade 4, Glioblastoma.
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GFAP expression
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Atrocytes
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Most common brain tumor
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Glioblastoma (also most malignant)
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Glioblastoma on CT scan
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Ring enhancement with surrounding edema
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Necrosis with perinecrotic pallisading
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Glioblastoma
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Pilocytic atrocytoma gross appearance
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Cystic cerebellar tumor, mural nodule. Benign, in children.
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Rosenthal fibers
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Brightly eosinophilic sausage-shaped structure seen in pilocytic astrocytoma. Shows benign nature of tumor.
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CT of oligodendroglioma
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Calcifications
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Microscopic appearance of oligodendrogliomas
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Fried egg pattern of cells; chickenwire vascular pattern; calcifications.
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Loss of heterozygosity of 1P,19q responds well to chemotherapy for which tumor?
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Anaplastic oligodendroglioma
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Most common location for ependymomas
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Fourth ventricle in children; spinal cord in adults.
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Microscopic appearance of ependymomas
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Perivascular pseudorosettes with anuclear sleeve
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Most common tumor causing temporal lobe epilepsy
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Ganglioglioma
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Which tumor starts from hemisphere and moves into ventricle? Which starts in ventricle?
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Medulloblastoma moves from hemisphere into ventricle; ependymoma starts in ventricle.
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Medulloblastoma
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Primitive small cell tumor of cerebellum. Predominantly in children.
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CT of meningioma
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Dural tail
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Meningioma micro
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Syncytium, whorling, psammoma bodies.
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Most common tumor of cerebello-pontine angle
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Schwannoma
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Presentation of Schwannoma
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Involves the VIIIth nerve, so hearing loss, disequilibrium, tinnitus.
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Primary CNS Lymphoma
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See in AIDS patients. Perivascular arrangement of malignant B cells.
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NF1 chromosome
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Ch17
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NFII chromosome
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Ch22
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NFII
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bilateral acoustic schwannomas
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Adenoma sebaceum, mental retardation, ash-leaf macule, cortical tumors, and subependymal hamartomatous nodules seen in what?
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Tuberous Sclerosis
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VHL Disease chromosome
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Ch3
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