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4 Cards in this Set
- Front
- Back
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Describe the role of each of the domains of Bd BAD1
hydrophobic region tandem repeat EGF-like domain |
hydrophobic region-secretion signal, release into media, T cell epitopes
Tandem repeat- binds CD11b/CD18 on macs, B cell/T cell epitope, calcium bindng, immunosupressive EGF like domain- adherence motif |
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Describe Bd's BAD1 immunoregulatory properties
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wild type expression of Bd BAD1 represses synthesis of host TNF-a via a TGF-B dependent and independent mechanism, tandem repeats are required for this function
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Which components of BAD1 are essential for virulence
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tandem repeats not EGF domain
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In what phase does Bd express BAD1
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yeast only, regulated transcriptionally
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