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10 Cards in this Set

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  • Back
List some other important S. aureus exotoxins and their mechanisms of action?
1. Coagulase-Activates clotting, preventing phagocytosis.
2. Staphylokinase- Lyses thrombi and prevents body from walling off an infection.
3. Hyaluronidase- lyses the connective tissue matrix facilitating spread.
4. hemolysin/leukocidin- Lyses RBCs(beta hemolytic) and WBCs.
5. Beta lactamase- Cleaves penicillin family(Beta lactam drugs)
S. aureus is the most common cause of postsurgical wound infections. What other skin infections are associated with S. aureus?
Impetigo/cellulitis, furuncles/carbuncles(hair follicle), mastitis(nursing breasts).
describe the lesion in impetigo.
Bullae that burst and become honey crusted.
What is used to treat methicillin sensitive S. aureus infections?
Beta lactamase resistant penicillin(nafcillin, dicloxacillin or Beat lactam/ beta lactamase inhibitor combination.
How is methicillin-resistant S. aureus (MRSA) treated?
Vancomycin/Bactrim, clindamicin, minocycline or ciprofloxacin, linezolid and daptomycin may also be used as alternatives.
What differentiates Staph. epidermidis from Staph. saprophyticus?
Novobiocin sensitivity. Staph. saprophyticus is the only Staphylococcus resistant to novobiocin.
What are the two typical diseases caused by S. epidermidis?
Prosthetic valve endocarditis and I/V catheter infection.
What allows adherence by S. epidermidis to prosthetic material?
Glycocalyx on its capsule.
What type of infection is S. saprophyticus associated with?
Second most common cause of UTIs in sexually active younger women.
How do you treat S. saprophyticus UTIs?
Fluoroquinolones or Trimethoprim-sulfamethoxazole.