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16 Cards in this Set
- Front
- Back
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How does the structure of IgM in its secreted form differ from its membrane bound form. What is the function of secreted IgM?
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Membrane bound IgM is a monomer, but secreted IgM a pentamer. IgM is the main antibody in the primary response of humoral immunity.
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How does the structure of IgM in its secreted form differ from its membrane bound form. What is the function of secreted IgM?
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Membrane bound IgM is a monomer, but secreted IgM a pentamer. IgM is the main antibody in the primary response of humoral immunity.
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IgG is the main antibody in the secondary response of humoral immunity, though both IgG and IgM can opsonize. How do they differ?
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IgG can directly opsonize, while IgM acts indirectly through complement activation.
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Microbial pathogens entering the nasopharynx will most likely encounter which immunoglobulin isotype?
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Dimeric IgA is concentrated in secretions(mucosa, tears, saliva, respiratory/intestinal/genital secretions)to neutralize microbial pathogens.
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What protects IgA from being digested by intestinal enzymes?
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The secretory component synthesized by epithelial cells protects IgA from proteolysis.
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What 2 immune processes does IgE mediate?
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Type 1 hypersensitivity,(allergy, anaphylaxis) and helminth immunity.
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Antibodies are found attached to the surfaces of which types of cells?
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B cells(IgM and IgD, recognition phase), mononuclear phagocytes(IgG, opsonization), NK cells(IgG, antibody dependent cellular cytotoxicity), mast cells and basophils(IgE, anaphylaxis), and eosinophils(IgE, helminth immunity).
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What isotype is most abundant in serum?
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IgG
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What isotype is produced in the largest amount?
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IgA. About 2/3 of all antibody production is IgA, found in secretions over extensive surface area of the body.
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Which immunoglobulin isotypes can initiate the classical complement cascade/
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IgG and IgM both have Fc regions which are recognized by C1q- the first molecule in the complement cascade.
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What is the most common immunoglobulin isotype found in fetal serum?
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Maternal IgG.
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Why is Igg the only maternal isotype found in the fetus?
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The Fc portion of the IgG molecule is recognized by a special type of Fc receptor in the placenta, thus facilitating its transfer.
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Why is Igg the only maternal isotype found in the fetus?
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The Fc portion of the IgG molecule is recognized by a special type of Fc receptor in the placenta, thus facilitating its transfer.
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Why is IgA the predominant isotype found in milk?
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Again this is due to specific Fc receptor Fc region mediated transfer of IgA, facilitating secretion of IgA into the breast milk.
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Why is IgA the predominant isotype found in milk?
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Again this is due to specific Fc receptor Fc region mediated transfer of IgA, facilitating secretion of IgA into the breast milk.
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What is the immunoglobulin isotype primarily produced by the fetus?
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IgM, but the fetus also produces very small amounts of IgG and IgA.
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