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27 Cards in this Set
- Front
- Back
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What causes lyme disease in USA?
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borrelia burgdorferi
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what is the morphology of borrelia burgdorferi?
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G- spirochete
microaerophile |
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What is the genome of borrelia burgdorferi?
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linear and circular plasmids
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Where are the filaments for borrelia burgdorferi located?
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flagella/axial filaments
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How long does it take to culture borrelia burgdorferi?
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SLOW, 4-14 days
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Where is borrelia burgdorferi most common?
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North eastern US (Connecticut)
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What are people usually doing when they get borrelia burgdorferi?
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out door activity in Tick infested areas
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What are common coinfections with borrelia burgdorferi in the new england area?
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Babesia Microti (babesiosis)
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What are the common coinfections with borrelia burgdorferi in the michgan and wisconsin area?***
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Anaplasma**
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What is the reservoir for borrelia burgdorferi?
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white footed mouse
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What are the two vectors for borrelia burgdorferi?
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Ixodes scapularis
Ixodes pacificus |
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is there transoviral passage of borrelia burgdorferi?
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No there is not
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How long do ticks need to feed for to transmit borrelia burgdorferi?
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about 48 hours, long time
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What stage of Ixodes is the major transmitter of borrelia burgdorferi?
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the Nymph/poppy seed stage
its hard to see because its small |
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What are the two virulence factors of borrelia burgdorferi?
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OSPA- binds to tick midgut
OSPC- invades human skin, establishes infection |
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What are the early signs of borrelia burgdorferi infection?
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localized infection, BULLS EYE RASH
red macule or papule can isolate spirochetes from leading edge |
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How long does it take to develop early disseminated borrelia burgdorferi?
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weeks to several months
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What are the signs of early disseminated lyme disease (borrelia burgdorferi)
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arthralgia and arthritis (TMJ)
multiple secondary bulls eye rashes neruological problems- bells palsy cardiac disease (heart block) |
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What are the signs of Late lyme disease?
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months to years late
lyme arthritis in large joints lyme neruopathy (radicular pain, cognnitive disturbances) |
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How do you diagnose borrelia burgdorferi?
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detect antibodies via ELISA
confirm ELISA with western blot |
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How do you treat borrelia burgdorfer?
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doxycycline
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What is Jarisch-Herxhemer response?
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this is rapid killing of spirochetes by the body- causes this response
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What are the symptoms of the Jarisch Herxheimer Response?
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restless, apprehensive
intense rigors temp,bp,rr all increase profuse sweating, BP drop |
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How often do people who get bitten develop lyme disease?
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only 3.2%
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What is the vector for STARI
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amblyomma americanum (lone star ticks)
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Where does STARI occur?
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south east and south central USA
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What are the symptoms of STARI?
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erythema migrans
similar to lyme disease |
