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39 Cards in this Set
- Front
- Back
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what is the vector for rickettsial diseases?
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arthropod borne
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How are rickettsial diseases maintained in the arthopod population?
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by transovarial transmission
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is there person to person tx of rickettsial diseases?
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no there is not
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what is the general morphology of rickettsial diseases?
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G- bacilli
obligate intracellular pathogens |
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what types of cells do rickettsial diseases go for?
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endothelial cells
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how do rickettsial diseases escape phagosomes?
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by using PLD, and hemolysin C
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what cells in the body do rickettsial diseases infect?
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vascular endothelial cells
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how do rickettsial diseases get into endothelial cells?
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by binding receptors and stimulating actin mediated phagocytosis.
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what are the symptoms of rickettsial diseases usually due to?
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bursting and damage to endothelial cells
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What are the symptoms of rickettsial diseases?
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hemorrhagic rash,
VERY high fever, severe head ache, edema, hypovolemia, thrombocytopenia, reduced profusions |
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where is RMSF most common?
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south eastern states
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when is RMSF most common?
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spring/summer
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Who gets RMSF?
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kids 5-9 years of age
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what is the vector for RMSF?
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ticks
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how long does the tick need to feed for to get RMSF?
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about 24-48 hours
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what are the symptoms of RMSF?
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high fever
severe frontal headache rash on wrist/ankles, that then spreads to the trunk (centripetal spread) |
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What is the vector for rickettsia akari?
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mouse mite
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what disease does rickettsia akari causes?
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rickettsialpox (looks like chicken pox)
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What is the first phase of rickettsia akari infection?
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a papule at bit site, within days 9-14
turns into an ulcer and eschar* (necrotic center) |
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what is the second phase of rickettsia akari infection?
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abrupt onset of fever
severe headaches chills, sweating, photophobia then a couple days later a pox-like rash all over body |
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Where is Rickettsia conorri common?
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mediterranean sea and parts of africa
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what does Rickettsia conorri cause?
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boutonneuse fever= mediterranean spotted fever
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what is the complication of Rickettsia conorri infection?
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severe neuro complications
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what is the presentaion of Rickettsia conorri?
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abrupt onset
HIGH fever SEVERE HA Eschar at bite site then spotted rash |
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Where is Rickettsia parkeri common?
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eastern/ southern usa
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what two bugs transmit Rickettsia parkeri ?
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gulf coast tick
lone star tick |
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what is the presentation of Rickettsia parkeri ?
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this is just like all other spotted fevers
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What is rickettia prowazerkii?
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this is epidemic typhus
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What is the vector for rickettia prowazerkii
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human body louse
usually by FECES* |
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What is the presentation of rickettia prowazerkii infection?
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1st phase: HIGH fever, Severe intractable HA
2nd phase: rash, centrifugal rash spread, spares face/palms/soles |
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Where is rickettsia typhi common?
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in the gulf states, urban cities/costal ports
in warm humid locations |
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What is the reservoir for rickettsia typhi?
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rat
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what is the vector for rickettsia typhi?
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rat flea Xenopsylla cheopis
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what does rickettsia typhi cause?
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murine or endemic typhus
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Where is O. tsutsugamushi common?
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E asia
asutralia japan west pacific islands |
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What is the reservoir for O. tsutsugamushi ?
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rodents and mites
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What is the vector for O. tsutsugamushi ?
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chiggers
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what disease does O. tsutsugamushi cause?
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scrub typhus
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how does the rash of O. tsutsugamushi move?
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centrifugally
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