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41 Cards in this Set

  • Front
  • Back
What is the invasive agent of toxoplasma?
sporozoites
what are the two ways to get toxoplasma?
oocyst- cats

troph- eating lamb
what happens with toxoplasma infection in susceptible peoples?
cysts in muscle and brain tissue

chorioretinitis
what are the signs of congenital toxoplasmosis?
hydrocephalus
mental retardation
cerebral calcification
chorioretinitis
what trimester is the worst to get toxoplasma?
1st trimester
What type of cat most commonly has toxoplasma?
feral cats
what is the diagnostic stage of toxoplasma?
tachyzoite and bradyzoite

ELISA serum
What is the vector for African trypansomiasis?
tetese fly
What is important about African trypansomiasis and its glycoproteins?
this bug will often switch its surface antigens and thus evade the immune system
what happens at the site of innoculation with African trypansomiasis?
big chancre sore
What are the classical manifestations of African trypansomiasis?
lymphadenitis
fever
somnolences

mental dullness
tremors of tongue
paralysis
where is African trypansomiasis located?
central and west africa

in HUMID forests**
what are the reservoirs for African trypansomiasis?
human and pig
what is the diagnostic stage of African trypansomiasis?
trypomastigote in blood (the flat worm like parasite stage)
What is the acute form of sleeping sickness?
trypanosoma rhodesiense
what are the signs of trypanosoma rhodesiense ?
sore/chancer
fever
lymphadenitis
parasetemia
How fast does trypanosoma rhodesiense kill?
quickly before the sleepiness occurs
where is trypanosoma rhodesiense located?
central and east africa

dry savanna woodlands
what is the vector for trypanosoma rhodesiense ?
tsetse flies
What is tyrpanosoma cruzi?
chagas disease
Where is tyrpanosoma cruzi common?
poor latin america
How do you get infected with tyrpanosoma cruzi?
kissing bug bites you, then poops the infective stage into the wound
what stage of tyrpanosoma cruzi is in the blood?
trypomastigote
what stage of tyrpanosoma cruzi is in the tissues?
amastigote
what is the acute phase of tyrpanosoma cruzi infection?
fever, fatigue, myalgia, large spleen, swollen glands

Romana's sign- swelling of eyelid

trypanosomes in blood
What are the chronic complications of tyrpanosoma cruzi?
cardiac!!

failure, arrest, ruputre, and cardiomyopathy
How does tyrpanosoma cruzi affect the GI nervous system?
this destroys the nervous tissue in the GI, causing megacolon and megaesophagus
how is tyrpanosoma cruzi transmitted?
arboborne (bugs), sexual, transfusion, transplacental
What is the infective stage of leishmania?
promastigote
What is the intracelular form of leishmaniasis?
amastigote
What bug causes leishmania?
sand fly
What are the signs of leishmaniasis
cutaneous ulcers develp at bite site
these ulcers are primary signs
What cell does leishmaniasis infect?
macrophages
What does Leishmania braziliensis cause?
this causes nasty ulcers and cartilage destruction
can you have recurrence with Leishmania braziliensis?
yes
does Leishmania braziliensis heal on its own?
yes it does
what causes mucocutaneous leishmania?
Leishmania braziliensis
What happens with recurrent Leishmania braziliensis?
advanced scarring
what are the signs of Leishmania donovani?
this attacks the internal organs

hepatosplenomegaly

fever
What is Post Kala-Azar?
this is recurrent Leishmania braziliensis due to Inadequate treatment
what is the treatment for Leishmaniasis?
stibogluconate sodium