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32 Cards in this Set
- Front
- Back
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What diseases does EBV cause?
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this causes infectious mononucleosis (US)
Burkitt lymphoma (foreign countries-africa) |
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What is the hallmark of infectious mono? (2)
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polyclonal B cell expansion
and T cells called "downey cells" against the polyclonal B cells |
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How long is the incubation of infectious mono?
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about 1-2 months
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What is the prodrome of infectious mono?
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prodrome of 3-5 days, headache, fever, malaise, fatigue
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What are the signs of infectious mono?
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sore throat, symetrical lymphadenopathy, fever, splenomegaly
palatal enanthem @ junction of hard/soft palate with petechia |
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what cell response causes the symptoms in infectious mono?
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T cell response
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what type of virus is EBV?
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this is a gamma herpesvirus- cant tx with any kind of antivirals
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what is the geneome of EBV?
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ds DNA
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what is the "attack rate" of EBV in college students?
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about 2%, which is high
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What is the best test for infectious mono?
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the heterophile antibody test
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what phase of EBV infection do heterophile antibodies occur?
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during the active infection stage
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are monospot tests accurate in preteens?
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no their immune systems are not mature yet
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Does CMV tests positive on a monospot?
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No you will not
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What type of virus is CMV?
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this is a betaherpesvirus
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What are the characteristic cell changes in CMV?
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this causes massive cellular enlargement with intranuclear "Owl's Eye" intracytoplasmic inclusions
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what happens when you give kids with EBV ampicillin?
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these is a massive rash all over the body
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What pt populations are most at risk for CMV?
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unborn
immune suppressed (with transplants or HIV) |
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are there usually symptoms for CMV infections in normal people
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there are typically No symptoms
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What is the presentation of CMV illness?
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heterophile negative mono like syndrome, typically in older pts
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What is a good reservoir for CMV thats a danger to expecting mothers?
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slimy gross babies
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What kinds of transplants have the highest risk of CMV?
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solid organs- kidney, heart, liver grafts
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What is the usual presentation of CMV in AIDS pts?
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90% is retinitis
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What is the treatment of CMV?
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gancicovir
fomivirisen IVIG |
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How do you diagnose CMV?
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giant cells
IgM ELISA culture and look for owl eye cells** |
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What type of virus is Mumps?
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paramyxovirus
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What is the genome of mumps?
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ssRNA non-segmented
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What are the virulence factors on the capsid of mumps?
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H and N
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What are the clinical manifestations of mumps?
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acute infection of salivary glands assocaited with painful swelling and fever
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How do you diagnose mumps?
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a febrile child with bilateral parotitis
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How many mumps cases are asymptomatic?
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30-40% are asymptomatic
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What are the main complications of mumps in adults?
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this can cause orchitis (testicular infection)
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can you still get mumps even if you get the MMR vaccine?
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yes you can
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