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15 Cards in this Set
- Front
- Back
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What is the Epithelial Ab?
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IgA
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Where is IgA produced?
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In mucosal lymphoid tissues
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What is IgA specialized for?
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Transport across mucosal epithelium
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What percent of the total daily antibody production consists of IgA?
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60-70%
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What factor stimulates production at mucosal surfaces?
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TGF-beta
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What molecule holds two IgA molecules together as a dimer?
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A J-chain
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How does IgA get across mucosal epithelial cells?
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By being bound to Poly-Ig receptor, and endocytosed as a complex by the epithelial cells.
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How does IgG get into the fetus?
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Via the fetal FcR
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What is Vaccination?
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The process of stimulating protective adaptive immunity to specific microbes by exposure to non-pathogenic forms or components of the microorganism.
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What is an "attenuated" microbe?
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One with diminished infectivity or pathogenicity.
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Can an attenuated microbe still generate an immune reaction?
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Yes, with robust formation of neutralizing antibodies!
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What is a technique that is done to increase the efficiency of protection conferred by a vaccine?
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Conjugate vaccine
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What is a conjugate vaccine?
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Injection of a microbial polysaccharide coupled to a protein
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Can vaccines only be done for antibody protection?
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No; vaccines can be directed against viruses too, with cell-mediated immune responses.
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What is the purpose of giving a live bacterial adjuvant along with a non-bacterial vaccination?
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A non-bacterial vaccine target alone will not upregulate B7, so it won't activate a cell-mediated memory very well. But give live bacteria will cause more presentation.
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