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47 Cards in this Set

  • Front
  • Back
Primary Pathology for Osteoarthritis?
Minimal inflammeation, Destruction of cartillage: Fibrillation, Eburnation, narrowing of joint space on x-ray, subchondral cysts, osteophytes associated with age
Polished ivory, seen in osteoarthritis
Bony outgrowth
Mlinical Manifestation of Osteoarthritis?
associated with age, F>M, pain, morning stiffness, Limitation of motion, Spine hip and knee, DIP,
Softening of Cartilage
Fixation of a joint
Pathology of Rheumatoid Arthritis?
Pannus, Destruction of articular cartilage, subchondrial bone exposure and destruction, bony ankylosis, nonsuppurative proliferative synovitis, lymphoid aggregates, no PMNs
Sseen RA, hypertrophy and chronic inflammation of synovium, dense lymphoid aggregates, no PMNs, nonsuppurative proliferative
Rheumatoid Arthritis is a systemic disease?
Skin: rheumatoid nodules
Blood vessels: vasculitis
Lungs, heart, valves, aorta, muscles
Amyloidosis secondary to inflammation
Antigen in Rheumatoid Arthritis?
Unknown, activates MHC class II
Possible causes for genetic susceptability in Rheumatoid Arthritis?
MHC type-II
CD4 and T-cells in Rheumatoid Arthritis?
Activated by antigen/MHC II complex and releases cytokines
Rheumatoid Factor?
IgM autoa-antibody to the Fc portion of autologous IgG, RA is 80% positive for RF
Clinical presentation of Rheumatoid Arthritis?
F>M, 20-30 y/o, RF, Symetrical, extremities
Seronegative Spondyloarthropathies?
HLA B-27
Ankylosing Spondylosis?
Seronegative Spondyloarthropathy (HLA B-27), Axial joints and uveitis, aortitis, amyloidosis
Reiter's syndrome?
Seronegative Spondyloarthropathy (HLA B-27), Urethritis, conjunctivitis, arthritis
Enteropathiic arthritis?
Seronegative Spondyloarthropathy (HLA B-27), IBD, arthritis
Psoriatic Arthritis?
Seronegative Spondyloarthropathy (HLA B-27), 10% of patients with psoriasis
Nonsuppurative infectious arthritis?
TB, Lyme, Viral
Pathogen and vector in Lymes disease?
Borrelia Burgdorferi, Ixodes scapularis(tick)
Three stages of lyme Disease?
Stage 1: Erythema Mignas, Weeks
Stage 2: Months, CNS and Cardiac
Stage 3: Destructive chronic arthritis
Tic transmitted diseases?
Lyme, STAR(southern tic associated rash), Ehrlichia, Babesia
Crystal arthropathies, hyperuricemia, arthritis, kidney disease, acute and chronic
Etiology of gout?
increase uric acid, increase neucleic acid turnover, decrease excretion, inborn errors
Pathology of Gout?
Monosodium urate crystals, Tophus: urates inside inflammatory tissue
Calcium pyrophosphate deposition disease(CPPD), Intraarticular crystal formation, idiopathic of herditary, no treatment
Baker's Cyst
Popliteal bursa (sac lined by synovium)
Synovial cyst, at wrist
Etiology of Soft tissue tumors?
Radiation, immunosuppression (AIDS), genetics: Neurofibromatosis, gardner syndrome...
Most common location for Soft Tissue Tumors?
Lower extremity(40%), Lower extremity(20%), Head and neck, trunk and retroperitoneal,
Angiolipoma location?
Upper extremity
Most common sarcoma in adult?
Indolent Liposarcoma?
Well differentiated
Myxoid Liposarcoma?
Round cell and pleomorphic liposarcoma?
Aggressive, nuclear scalloping, mimics fetal fat cells
Reactive pseudosarcomas?
Nodular Fascitis, myositis ossificans
Myositis Ossificans?
Metaplastic bone, young history of trauma, swelling, pain, circumscribed and firm, DD could be extroaskeletal osteosarcoma
Dupuytren contracture?
Palmar superficial fibromatosis
Peyronie disease?
Fibromatosis of dorsal penis
Rare, aggressive, retroperitoneal, thigh knee and distal extremities
Herring bone pattern
Benign, common, dermis, subcutis, mid-adult
Malignant Fibros Histiocytoma?
Pleomophism, Storiform (cartwheel), Muscles in proximal extremities, Retroperitoneum, large and aggressive
Skeletal muscle, children, head and neck and GU(bladder and vagina)
Benign, smooth muscle tumor, uterine fibroids, most common neopleoplasm in women, Fascicles intersecting at right angles
adults, f>m, Retroperitoneam, extremities
Synovial sarcoma?
Biphasic, epithelial like spindle, 70% lower extremities, 20-40 y/o, SYT-SSX1 or 2 fussion genes