INTRODUCTION
Osteoarthritis is a disease, which results from mechanical and biological events that destabilize the normal processes of degradation and synthesis of articular cartilage chondrocytes, extracellular matrix, and subchondral bone. These changes include increased water content, decreased proteoglycan content, and altered collagen matrix, all leading to the deterioration of articular cartilage. Osteoarthritis can be classified into primary and secondary types Primary osteoarthritis generally is a polyarticular degenerative arthritis of unknown origin that may be active to some extent in several joints and rarely occurs before the age of 35 years. Secondary osteoarthritis is usually mono-articular in which the reaction of
Osteoarthritis is a disease, which results from mechanical and biological events that destabilize the normal processes of degradation and synthesis of articular cartilage chondrocytes, extracellular matrix, and subchondral bone. These changes include increased water content, decreased proteoglycan content, and altered collagen matrix, all leading to the deterioration of articular cartilage. Osteoarthritis can be classified into primary and secondary types Primary osteoarthritis generally is a polyarticular degenerative arthritis of unknown origin that may be active to some extent in several joints and rarely occurs before the age of 35 years. Secondary osteoarthritis is usually mono-articular in which the reaction of