Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
HHV?
p97 |
human herpesvirus. fragile, enveloped and becomes latent throughout life. 8 types. periods of transmissibility/replication
|
|
|
where might HHV camp out?
how are they spread? p97 |
will be latent in neurons, macrophages, or lymphocytes (t or b cells)
spread via mucosal-mucosal contact (exception: varicella/zoster, via respiratory droplets to lung mucosa) |
|
|
1. T/F HHV are extremely common
2. t/f aren't uiquitous, benign or morbidity 3. ssDNA genome, suseptable to antiviral therapy p98 |
1. t
2. f . are ubiquitous 3. f . dsDNA |
|
|
1. t/f fully assembled before reaching cytoplasmic memB
2. t/f typical secondary mucosal epithelium infection 3. t/f multiple relapses common 4. t/f acyclovir is antibiotic for HHV p98 |
1. t
2. f - 1' mucosal epithelium infection 3. t 4. antivirus used in therapy |
|
|
common names for HHV #1-8?
p98 |
1.) herpes simplex virus 1
2.) '' '' 2 3.) Varicella Zoster virus 4.) Epstein Barr Virus 5.) Cytomegalovirus (6-7 none) 8.) Kaposi's Saroma Virus |
|
|
Imprtant dieseases of HHV from #1-8
p98 |
1. cold sore, oral ulcers
2. genital herpes 3. chicken pox, shingles 4. Mono, burkitt's lymphoma 5. congenital infection 6 - 7. roseola nfantum 8. kaposi's sarcoma |
|
|
initial virual infection usually on mucosa, spread via blood (viremia) to other organs. dangerous to fetus? what's body's immune response?
p99 |
during viremia stage, can be dangerous to fetus. Th, Tc, B cells clone. TC (&NK) kill 'virual factories'. B cells Ab's neutralize virus particles. some virus hides in host DNA latently, and cold sores regularly
|
|
|
latent viruses become reactivated, ie coldsore - causing release of many new viral particles - viremia?
p99 |
not this time.
Memory T and B cells respond so quick it keeps everything local. Local damage seen b/c virus & b/c Tc killing spree |
|
|
mechanism of viral entry into a cell, occurs how?
p100 |
via interaction of viral spike proteins with cell surface Receptors. nucleocaspid thru cytoplasm and fuses envelope with Nu, releasing genome.
|
|
|
viral mechanism within infected host cell and viral exit?
p100 |
DNA (viral) - immediate early genes, delayed early genes and late genes. IN nucleus acquire envelope (and spikes) and head out
|
|
|
what is the #1 leading cause of blindness in the USA?
p 101 |
herpes simplex virus - 1. keratitis. common cause for corneal transplantation.
|
|
|
1. t/f 60-80% usa get HSV-1.
2. t/f 80-100% get HSV - 2 3. t/f encephalitis is from HSV-2 4. t/f herpes genitalis is STI from HSV - 2 p101 |
1. t, most before adulthood
2. f - 20-25%, typically aquired post adolescence 3. f - from HSV - 1 4. t - genital ulcer diseas from HSV-1 is rising too. increases risk of getting HIV 2-4 fold |
|
|
t/f vaccines fro HSV 1 & 2 are greatly encouraged for those in the HIV category
p 101 |
f - a vaccine is urgently needed
|
|
|
if the mucoepithelium is initally infectd, what is latently infected?
p102 |
the sensory ganglia
|
|
|
what's the difference of spreading HSV-1 vs HSV-2?
p102 |
both mucosal/mucosal. HSV-1 most often in children (oral, oral).
HSV-2 via sexual contact (genital-genital, genital-oral) |
|
|
what makes VZV unique among HHV's?
p 103 |
Varicella-zoster v's have 1' infection of chicken pox, and 2' of Shingles. Only one spread via respiratory droplets, no intimate mucosal contact required. PLUS a vaccine is availible.
|
|
|
progression of varicella ('pox') zoster ('shingles')?
p 103 |
infects lung mucosal epithelium, then local lymph nodes, then enters blood and finally skin epithelial cells, then pox seen.
skin area by single nerve root gets recurrent |
|
|
immunosupressed treatment for someone coming down with VZV?
p104 |
anti-VZV antibody
anti-viral acyclovir |
|
|
what are the symptoms of the "kissing disease"?
p105 |
fever, sore throat, swollen lymph nodes (lymphadenopathy) and more mononuclear cells (infected B and Tc (attacker) cells. FATIGUE. >95% population has previous infection
|
|
|
african children and epstein barr virus, what's the association with malignancy?
p105 |
EBV was found in malignant tissues, first virus related to malignancy. associated with malaria.
also associated with Hairy Leukoplakia and nasoplaryngeal cancers |
|
|
1. t/f EBV linked with burkitts lymphoma & nasopharyngeal carcinoma
2. t/f kaposis sacoma causes liver cancer (chronic infection) 3. hep B/C viruses causes kaposi's sarcoma 4. HTLV-1 - like to cervical/oral cancers p105 |
1. true. 2. kaposi's sarcoma = kaposi's sarcoma
3. Hep b/c = linked with liver cancer in people with chronic infections 4. HTLV - a retrovirus linked to T-cell leukemia HPV - liked with cervical/oral cancers |
|
|
why is saliva contact going to spread EBV?
p 106 |
the latent lifelong infection continually shed into saliva
|
|
|
what is the most common virus transmitted to a fetus, causing permanent diabilities to child? where's this problems seen?
p107 |
Cytomegalovirus - common, infected small children mostly (no symptoms). in Developed country problem b/c we don't get infection as a young child (thus develop no neutralizing Ab's)
|
|
|
how is Cytomegalovirus spread?
p107 |
CMV is spread via all bodily fluids including saliva and semen. usually asymptomatic disease
|
|
|
although usually asymptomatic disease, when is CMV dangerous?
p107 |
for pregnant ladies (if they get it for the first time while prego)
reactivation problem in immunospressed (transplant pt's, AIDS) may = death. |
