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11 Cards in this Set

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How does a prion and native protein differ?
Prions are infectious agents that differ from native proteins only in conformation (folding).
Bulky amino acids are more likely to be found in [ alpha helices / beta sheets ].
beta sheets
In turn or loop regions, what two amino acids are more likely to be found?
gly and pro
Two examples of fibrous proteins are major structural protein of connective tissue ______________ and major structural protein of hair and nails ____________. Which is made of cross-linked alpha helix protomers and which is of cross-linked helical (left-handed) protomers?
collagen - connective tissue, helical (left handed)

keratin - hair and nails; alpha helix
True or False: Collagen is formed with left-handed helices.
True.

Keratin, found in hair and nails and another example of fibrous protein, is formed with alpha helices but collagen, found in connective tissue, is formed with helical protomers.
Tight junctions between the collagen subunits are permitted by Gly residues in the Gly-X-Y repeating unit where Y is usually a ________ residue.
HyPro (hydroxyproline). Vitamin C is involved in the formation of HyPro. Thus Vitamin C comes into play in health of connective tissues, particularly collagen.

fun fact: Cross links increase as you get older making your collagen more rigid.
With regards to a general protein like a globulin, where would you probably expect to find
(a) Pro
(b) Glu
(c) Arg
(d) Leu
(e) Thr
(f) Asn
(a) Pro - at turns/folds
(b) Glu- acidic, outside
(c) Arg - basic, outside
(d) Leu - nonpolar, inside
(e) Thr - polar, outside (or inside interacting with another polar molecule inside or H2O)
(f) Asn - polar, same as (e)
True or False: Motifs are specific combos of secondary structural elements (beta sheets, alpha helices in special conformations like barrels, other loops, crossovers) that recur in proteins and that have specific functions in proteins sometimes allowing you to classify proteins, providing a structural basis about what’s going on by analogy to what happens with analogous proteins.
True!
_______ are regions of the protein that tend to retain their characteristic structure even when separated from the rest of the protein. These are also often associated with a specific function.
Domains.

examples are: catalytic, substrate binding, regulatory, membrane binding, immunoreactive
True or False: Information necessary for proper folding of a protein doesn't always reside just in its primary amino acid sequence.
True. Chaperones, proteins that provide templates for protein folding, help.
Prions are the only known infectious agents that lack ________.
lack nucleic acids. All prions "act" by altering the conformation of native prions in the brain or neural tissue.