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8 Cards in this Set
- Front
- Back
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Myeloblast
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The earliest recognizable cell in the granulocytic series
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Promyelocyte
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Primary azurophilic granules (numerous lysosomal enzymes, bacterialcidal factors, myeloperoxidase (MPO) positive
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Neutrophilic myelocyte
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No more production of primary granules. Secondary, specific, neutrophilic granules. 2 major proteins: lactoferritin & gelatinase, MPO negative. Responsible for the pink background in neutrophils. "Dawn of neutrophilia" Acquire some motility. Last cell acpable of mitosis.
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Neutrophilic metamyelocyte
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No more mitosis. Cessation of DNA synthesis. Indented <1/2 width of the nucleus, kidney-shaped nucleus. As cell matures, primary granules lose their intense staining characteristics. End of this stage, tertiary granules - gelatinase granules
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Neutrophilic band
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Indentation of >1/2 width of the nucleus. Possess full motility, active adhesion properties, and SOME phagocytic ability
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Polymorphonuclear neutrophil
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Completely functional. Usually 2-4 lobes of segmented nucleus. Phagocytosis. Pinocytosis
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Neutrophil series
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Mitotic stages (myeloblast, promyelocyte, myelocyte). Postmitotic stages (metamyelocyte, band, PMN). 14 days to get into the peripheral blood. Circulating granulocyte pool (CGP) and marginal granulocyte pool (MGP). Half life (T1/2) in blood = 6hrs; in tissues = a few days (1-2 days if used in inflammatory exudate, secreted, or removed by RES.
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Cell maturation characteristics
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Cell size decreases, decreased nuclear-cytoplasmic ratio, increased flexibility and mobility (cells are able to move through sinusoids of BM).
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