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12 Cards in this Set
- Front
- Back
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Is there more anaerobes or aerobes found in the colon?
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Anaerobes
E. Coli is not the most present cell btw |
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What are predisposing factors that lead to anaerobic infections?
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1. Low Redox Conditions due to Circulatory Problems
2. Antibiotic Therapy can lead to Clostridium difficle infection 3. Bite Wounds 4. Aspiration of mouth flora into the lungs 5. Spillage of intestinal contents into peritoneal cavity due to perforation of GI tract |
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Where in the body are anaerobes found as normal flora?
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Skin
Mouth Vagina Colon |
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Why are anaerobes sensitive to Oxygen?
3 Reasons |
Lack Catalase -- breaks down H2O2
Lack SOD -- detoxifies free radical forms of O2 Enzymes sensitive to O2 |
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Strict anaerobes
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Killed by O2
Grow in absence of O2 |
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aerotolerants
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Only use fermentation but survive in O2 or out of O2
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faculative anaerobe
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Grow in presence or absence of O2
-- no O2 --> fermentation O2 --> respiration E. Coli |
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microaerophile
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Special group of aerobes requiring O2 at lower concentrations than found in normal air
Campylobacter spp. |
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aerobe
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Grow only in presence of O2
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1. What is the name of 2 iron binding proteins human cells use?
2. How do pathogens overcome host iron sequesteration? 2 ways. Specific bacteria that does second one. |
1. Lactoferrin and Transferrin
2. a) Siderophores = bacterial iron binding molecule b) Bacteria bind Lactoferrin and Transferrin to their surface and then use that bound iron -- Neisseria spp. |
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Phases of Bacterial Growth
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Lag - Exponential - Stationary
In stationary there are both viable and NON viable bacterial cells In exponential, you can determine doubling time based on slope |
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Two types of anaerobic infections
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Clostridal = toxin mediated
Non-clostridal = non-toxin mediated |
