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3 Cards in this Set
- Front
- Back
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What two pharmacological principles does genetic polymorphism affect? |
- Pharmacokinetics = ADME
- Pharmacodynamics = receptors, enzymes, ion channels, immune system |
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Describe some inter-individual variabilities in drug metabolism |
Lack of metabolism - leads to inc plasma concentrations and exaggerated drug effects Lack of a detox pathway - means increased toxicity Lack of a bioactivation pathway - they make less toxic but also less good effects Increased Protein expression or catalytic activity - make more proteins |
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Lack of detoxicification resutling in enhanced pharmacological activity |
a |
