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What two pharmacological principles does genetic polymorphism affect?
- Pharmacokinetics = ADME
- Pharmacodynamics = receptors, enzymes, ion channels, immune system
Describe some inter-individual variabilities in drug metabolism
Lack of metabolism - leads to inc plasma concentrations and exaggerated drug effects
Lack of a detox pathway - means increased toxicity
Lack of a bioactivation pathway - they make less toxic but also less good effects
Increased Protein expression or catalytic activity - make more proteins
Lack of detoxicification resutling in enhanced pharmacological activity
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