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7 Cards in this Set
- Front
- Back
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List 5 primary glomerular disorders, per step up.
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minimal change dz
focal segmental glomerulosclerosis (FSGS) membranous nephropathy IgA / Berger's Dz Hereditary nephritis / Alport's Dz 284-5 |
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What is is the presentation of nephrotic syndrome?
What are the two most common causes of nephrotic syndrome in adults? What is the most common cause in children? |
>3.5 g / day urine protein
hypoalbuminemia --> edema hyperlipidemia / fatty casts in urine hypercoagulable state (due to loss of anticoag factors in urine) increased risk of infection (due to loss of immunoglobulins in urine) In adults: Membranous nephropathy and FSGS. In kiddies: Minimal change dz 284 |
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Which primary glomerulopathy is described?
Sometimes ass with lymphomas. Fusion of foot processes on EM. What is the prognosis and treatment? |
This describes minimal change dz.
Is the most common cause of nephrotic syndrome in kids. Prognosis is good with 4-8 weeks of steroid therapy. Relapses might occur. p284 |
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Which primary glomerulopathy is described?
Hematuria and HTN is often present. See effaced foot processes on EM Generally resistant to steroid therapy. Is one of two most common causes of nephrotic syndrome. What is the prognosis and treatment? |
FSGS
Fair-poor prognosis. Most develop renal insufficiency in 5-10 years of diagnosis due to progressive course. Treatment regimen controversial. Some pts have achieved remission with use of cytotoxic agents, steroids and immunosuppressive agents. ACE/ARBs help too. p284 |
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Which primary glomerulopathy is described?
- primary dz is idiopathic. secondary form due to infection, (Hep C, Heb B, syphilis, malaria), drugs (gold, captopril), neoplasm or lupus. - is one of two most common causes of nephrotic syndrome. - steroid therapy does NOT change survival rate What is the prognosis and treatment? |
membraouns nephropathy
fair to good prognosis. variable course and remission common in 40% of cases but 33% of cases advance to renal failure eventually p284 |
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Which primary glomerulopathy is described?
- most common cause of glomerular hematuria worldwide. - asymptomatic recurrent hematuria/ mild proteinuria - gross hematuria might occur after a URI or exercise - renal function is normal - mesangial deposiiton of IgA and C3 on EM What is the prognosis and treatment? |
IgA nephropathy / Berger's dz
Prognosis is goo in most as renal function is preserved generally. No therapy has been proven effective though some advocate steroids. p284 |
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Which primary glomerulopathy is described?
Hematuria, pyuria, proteinuria, high frequency hearing loss without deafness, progressive renal failure. What is the prognosis and treatment? |
Hereditary nephritis / Alport's syndrome.
No effective treatment p285 |
