Integ Test 1

Front 1

Zafirlukast or Montelukast

Back 1

Leukotriene Antagonists - reduce inflammation

Front 2

First generation H1 Antagonists

Back 2

Hydroxyzine (Atarax), Chlorpheniramine, Diphenhydramine, Cyproheptadine (Periactin)

Pass BBB; sedation

Front 3

Second generation H1 Antagonists

Back 3

Loratadine (Claritin) and Cetirizine (Zyrtec)

Don't pass BBB; non-sedated

Avoid use with imidazole antifungals and macrolide antibiotics

Front 4

H2 Antagonists (~15% of skin “H” receptors are H2 type)

Back 4

Cimetidine (Tagamet), Ranitidine (Zantac), Famotidine (Pepcid) and Nizatidine (Axid). Use caution with cimetidine (interactions!!)

Front 5

Doxepin

Back 5

Anti-depressant

H1 blockade is key, maybe H2

Front 6

Side effects of steroid

Back 6

Photosensitivty
Decreased immune system.

Front 7

Methotrexate

Back 7

Anti-metabolites

Folic acid analog used to inhibit DHFR

avoid drug interactions with other folate antagonists(trimethoprim/sulfas) and avoid co-administration with aspirin or NSAIDs that displace the drug from protein binding sites and promote toxicity

Front 8

Hydroxyzine !!!!!!!!!!!!!!!!!!!!!!!!!!
Diphenhydramine
Cyproheptadine

Back 8

H1-receptor antagonists
First Generation

Front 9

Fexofenadine
Desloratadine
Loratadine
Cetirizine

Back 9

H1 receptor antagonist Second Generation

Front 10

Ranitidine
Famotadine

Back 10

H2 receptor antagonist

Front 11

Which antihistamine drug cause weight gain?

Back 11

cyproheptadine

Front 12

Doxepin

Back 12

Tri-cyclic antidepressant with potent H1 and H2 histamine blockade activity

Mainly used in chronic urticaria

Anticholinergic effects

Front 13

What drug is used to treat Corticosteroid resistant chronic urticaria

Back 13

Methotrexate -antifolate

Front 14

Epipen Dose

Back 14

0.3 ml / 03ml

1:1000

Front 15

Epipen JR. Dose

Back 15

0.15 mg / 0.3ml

1:2000

Front 16

ampicillin, amoxicillin, penicillins, cephalosporins, monobactams, carbapenems

Back 16

inhibitors of cell wall synthesis

Front 17

tetracyclines, aminoglycosides and streptogramins

Back 17

30S protein synthesis inhibitors

Front 18

erythromycin, clindamycin or chloramphenicol

Back 18

50S protein synthesis inhibitor

Front 19

rifampin, quinolones and the “antimetabolite” sulfonamides and trimethoprim – folic acid disruption

Back 19

Inhibitors of nucleic acid function or synthesis

Front 20

daptomycin, polymixins

Back 20

Inhibitors of cell membrane permeability/function

Front 21

Do erythromycin and rifampin interact with each other?

Back 21

inhibitors (erythromycin) and inducers (rifampin) of drug metabolism

Front 22

ciprofloxacin

Back 22

quinolone

inhibit topoisomerases to interrupt DNA functions.

Front 23

Grieseofulvin

Back 23

Anti-fungal

Disrupt microtubule system and mitosis

Fungistatic

Dosing issues and questions about efficacy

Front 24

Terbinafine

Back 24

- antifungal
- inhibit conversion of squalene --> lanosterol; squelen epoxidase
- Well-absorbed, but suffers 40% metab due to first pass effect in liver; 99% protein bound so watch PK of other meds
- T1/2 up to 200-400 hrs

Front 25

Another similar agent to terbinafine

Back 25

naftitine

Front 26

Cimetidine does what do P450

Back 26

inhibit cyp450

Front 27

Drug interactions of Terbinafine

Back 27

Rifampin decreases / Cimetidine increases plasma concentrations of Terbinafine via P450 effects

Front 28

ketoconazole, miconazole are what group of azole

Back 28

imidazoles

Front 29

fluconazole, itraconazole, voriconazole, posaconazole are in what group of azole?

Back 29

triazole

Front 30

The MOA of the topical antibiotic mupirocin is inhibition of:

Back 30

Leu-tRNA synthetase

Front 31

80% of this drug is excreted unchanged in the urine.

Back 31

Fluconazole

Front 32

Drug with FDA indication for onychomycosis and better for Candida infections

Back 32

Itraconazole (Sporanox)

Front 33

Brand name of terbinafine

Back 33

Lamisil

Front 34

Best drug for onychomycosis?

Back 34

Terbinafine (Lamisil)

more effective than itrconazole

Fungicidal

Front 35

Drug for Tinea Pedis

Back 35

Griseofulvin
Fluconazole
Terbinafine

Front 36

Treatment for tinea capitis

Back 36

Ketoconazole shampoo
Topical antifungal solution and lotions
Selenium sulfide
Topical steroids

Griseofulvin
Fluconazole
Itraconazole
Terbinfine

Front 37

Tinea Barbae treatment

Back 37

Requried oral since topical cannot penetrate hair follicles

Griseofulvin
Fluconazole
Itraconazole
Terbinafine

Front 38

Tinea Corporis treatment

Back 38

topical antifungal therapy
aluminum acetate for wet lesions

griseofulvin
fluconazole
ketoconazole
itraconazole
terbinafine

Front 39

Treatment for Tinea cruris (jock itch

Back 39

topical steroid/antifungal
powder
aluminum acetate

Griseolfulvin
Ketoconazole
fluconazole
itraconazole
terbinafine

Front 40

treatment for tinea manuum

Back 40

terbinafine
itraconazole
griseolfulvin

Front 41

treatment for tinea manuum

Back 41

terbinafine
itraconazole
griseolfulvin

Front 42

Major Burn Injury

Back 42

2nd degree
>25% BSA for adult
>20% BSA for children

3rd degree >10% BSA

Electrical

Front 43

Moderate, uncomplicated burns

Back 43

2nd degree
15-25%BSA in Adult
10-20% BSA in children

3rd degree 2-10% BSA

Front 44

Minor Burn Injury

Back 44

2nd degree
<15% BSA in adults
<10% BSA in children

3rd degree <2%BSA

Front 45

Surgical referral is usually made for all patients with deep second or third-degree burns covering _____% BSA

Back 45

3

Front 46

Silver Sulfadiazine (Silvadene)

Back 46

topical antimicrobial
agent of choice
broad spectrum
pentrate eschar tissue
lack good water solubility
not useful for established infection
free of acid/base & electrolyte disurbances
systempic abospritoin (neutropenia)
do not use in pregnancy

Front 47

Mafenide Acetate (Sulfamylon)

Back 47

water soluble
penetrate eschar areas
best for contaimnated burn wounds or if bacterail growth is evidence

adr: inhibit carbonic anhydrase --> increase carbonate excretion and hyperventilation -->metabolic acidosis

Front 48

silver nitrate

Back 48

antimicrobial

solution applied to multilayered gauze dressing --> "wet dressing"

anticipate loss of electrolytes --> be prepared to replace them

not useful for established infection --> must apply immediately

Front 49

Wet dressings

Back 49

Aluminum Acetate (Burow’s Solution)
Actions - Mild germicidal and astringent activity

Potassium Permanganate
Actions – Moderate germicidal activity; not astringent

Silver Nitrate
Actions – Good germicidal and astringent activity

Acetic Acid
Actions – Good germicidal and astringent activity

Front 50

allantoin, calamine, white petrolatum or zinc oxide

Back 50

topical protectants for minor burns

Front 51

oval lesion with dusky red-blue appearance

drug treatment may not be affected

Back 51

fixed drug rxn

Front 52

aceneiform eruptions can be caused by what drugs

Back 52

contraceptive, coriscosterone, lithium, idodide

Front 53

oval lesion with dusky red-blue appearance

drug treatment may not be affected

Back 53

fixed drug rxn

Front 54

aceneiform eruptions can be caused by what drugs

Back 54

contraceptive, coriscosterone, lithium, idodide

Front 55

FDA warnings of itraconazole

Back 55

CHF
Hepatoxicty

Front 56

True/False. Systemic antibiotics are not effective for burn patients.

Back 56

True - due to poor circulation at burn.

Front 57

allograft

Back 57

human skin

Front 58

xenograft

Back 58

pig skin