Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
define preload
|
End diastolic volume, amount of blood that enters during diastole and causes passive stretching of cardiac muscle
|
|
|
define afterload
|
pressure that the heart pumps against to eject blood (aortic P)
|
|
|
define inotrope
|
drug that alters strength of contraction of cardiac muscle (can be positive or negative)
|
|
|
define lusitrope
|
drug that alters relaxation of cardiac muscle (positive or negative)
|
|
|
define chronotrope
|
drug that alters rate of contraction of cardiac muscle (positive or negative)
|
|
|
What is the mechanism of action for Digoxin?
|
Na/K ATPase inhibitor
- positive inotrope because it allows Ca to enter the the cell via increased action of the Na/Ca exchanger |
|
|
What is Digoxin used for?
|
correcting atrial fibrillation (used to be used in heart failure, not so much anymore)
|
|
|
What is the mechanism of action of Pimobendan?
|
Phosphodiesterase III inhibitor
- positive inotrope, vasodilator (arterial and venous) by increasing levels of cAMP and increasing sensitivity of troponin C for Ca to enhance binding |
|
|
What is Pimobendan used for?
|
reduces afterload and preload, approved for use in dogs
|
