Na+/K+ Pump and the Secondary Active Transport of Glucose The concentration gradient of sodium ions produced by the sodium potassium pump possesses potential energy that is utilized as sodium ions move down the concentration gradient during secondary transport. [5]. The sodium gradient propels the absorption of glucose in the glucose sodium cotransporter, SGLT1 [6]. SGLT1 uses the sodium gradient to move the glucose molecule down the gradient since it does not have its own energy to do so [6]. The sodium ion pulls molecule with it as it goes back into the cell through carrier proteins. Na+/K+ Pump and the Heart
The regulation of Na+/K+-ATPase is important to the muscle tissue of the heart, the myocardial [4]. The ATPase enzymes determine the “set point” and regulate contraction of the cardiac and vascular muscles [4].
Heart Diseases. There is a correlation …show more content…
One of the roles of the sodium-potassium pump is to be a receptor for cardiotonic steroids (CTS) [3]. Cardiotonic Steroids consist of substances that contain steroid glycosides and they are inhibitors of the sodium-potassium pump. These cardiotonic steroids inhibit the pumping action produced by the enzymes of the sodium-potassium pump [3]. In the heart, these inhibitors increase the force of contraction and regulate contractility [10].
Digoxin
Digoxin is from a digitalis plant which binds to the extracellular side of the sodium potassium pump meaning that it binds to potassium. The inhibition of the sodium potassium pump makes calcium more abundant to other proteins. This leads to the force of the heartbeat to be stronger while decreasing the speed of the heart rate [9]. It is used to treat patients with cardiovascular disease. It works by making the heart beat stronger in a more regular rhythm. Digoxin had a beneficial effect on morbidity of patients with heart disease without affecting the mortality of the patients [9].
The regulation of Na+/K+-ATPase is important to the muscle tissue of the heart, the myocardial [4]. The ATPase enzymes determine the “set point” and regulate contraction of the cardiac and vascular muscles [4].
Heart Diseases. There is a correlation …show more content…
One of the roles of the sodium-potassium pump is to be a receptor for cardiotonic steroids (CTS) [3]. Cardiotonic Steroids consist of substances that contain steroid glycosides and they are inhibitors of the sodium-potassium pump. These cardiotonic steroids inhibit the pumping action produced by the enzymes of the sodium-potassium pump [3]. In the heart, these inhibitors increase the force of contraction and regulate contractility [10].
Digoxin
Digoxin is from a digitalis plant which binds to the extracellular side of the sodium potassium pump meaning that it binds to potassium. The inhibition of the sodium potassium pump makes calcium more abundant to other proteins. This leads to the force of the heartbeat to be stronger while decreasing the speed of the heart rate [9]. It is used to treat patients with cardiovascular disease. It works by making the heart beat stronger in a more regular rhythm. Digoxin had a beneficial effect on morbidity of patients with heart disease without affecting the mortality of the patients [9].